| Fullerenol C60(OH)24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line. | |
MedLine Citation:
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PMID: 18285660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pre-treatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismutase and glutathione peroxidase in irradiated K562 cells. |
Authors:
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Visnja Bogdanović; Karmen Stankov; Ivana Icević; Dragan Zikic; Aleksandra Nikolić; Slavica Solajić; Aleksandar Djordjević; Gordana Bogdanović |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-16 |
Journal Detail:
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Title: Journal of radiation research Volume: 49 ISSN: 0449-3060 ISO Abbreviation: J. Radiat. Res. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-21 Completed Date: 2008-07-25 Revised Date: 2012-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0376611 Medline TA: J Radiat Res Country: Japan |
Other Details:
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Languages: eng Pagination: 321-7 Citation Subset: IM |
Affiliation:
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Institute of Oncology, Department of Experimental Oncology, Sremska, Kamenica, Serbia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Free Radical Scavengers
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pharmacology* Fullerenes / pharmacology* Glutathione Peroxidase / metabolism Humans K562 Cells Leukemia, Erythroblastic, Acute / enzymology* Radiation-Protective Agents / pharmacology* Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Fullerenes; 0/Radiation-Protective Agents; 182024-42-6/fullerenol; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
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