Document Detail

Fullerenol C60(OH)24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line.
MedLine Citation:
PMID:  18285660     Owner:  NLM     Status:  MEDLINE    
Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pre-treatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismutase and glutathione peroxidase in irradiated K562 cells.
Visnja Bogdanović; Karmen Stankov; Ivana Icević; Dragan Zikic; Aleksandra Nikolić; Slavica Solajić; Aleksandar Djordjević; Gordana Bogdanović
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-16
Journal Detail:
Title:  Journal of radiation research     Volume:  49     ISSN:  0449-3060     ISO Abbreviation:  J. Radiat. Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-07-25     Revised Date:  2012-03-28    
Medline Journal Info:
Nlm Unique ID:  0376611     Medline TA:  J Radiat Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  IM    
Institute of Oncology, Department of Experimental Oncology, Sremska, Kamenica, Serbia.
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MeSH Terms
Free Radical Scavengers / pharmacology*
Fullerenes / pharmacology*
Glutathione Peroxidase / metabolism
K562 Cells
Leukemia, Erythroblastic, Acute / enzymology*
Radiation-Protective Agents / pharmacology*
Superoxide Dismutase / metabolism
Reg. No./Substance:
0/Free Radical Scavengers; 0/Fullerenes; 0/Radiation-Protective Agents; 182024-42-6/fullerenol; EC Peroxidase; EC Dismutase

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