| Fullerene derivatives: an attractive tool for biological applications. | |
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MedLine Citation:
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PMID: 14642323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fullerene family, and especially C60, has very appealing photo-, electro-chemical and physical properties, which can be exploited in many and different biological fields. Fullerene is able to fit inside the hydrophobic cavity of HIV proteases, inhibiting the access of substrates to the catalytic site of the enzyme. It can be used as radical scavenger; in fact some water-soluble derivatives are able to reduce ROS concentrations. At the same time, if exposed to light, fullerene can produce singlet oxygen in high quantum yields. This action, together with the direct electron transfer from excited state of fullerene and DNA bases, can be used to cleave DNA. In this review we report the most recent aspects of fullerene biological applications. |
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Authors:
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Susanna Bosi; Tatiana Da Ros; Giampiero Spalluto; Maurizio Prato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: 38 ISSN: 0223-5234 ISO Abbreviation: Eur J Med Chem Publication Date: 2003 Nov-Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: France |
Other Details:
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Languages: eng Pagination: 913-23 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, 34127 Trieste, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / chemistry, pharmacology, therapeutic use Apoptosis / drug effects, physiology Fullerenes / chemistry*, pharmacology, therapeutic use* Humans Osteoporosis / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Fullerenes; 99685-96-8/fullerene C60 |
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