Document Detail


Fullerene derivatives: an attractive tool for biological applications.
MedLine Citation:
PMID:  14642323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fullerene family, and especially C60, has very appealing photo-, electro-chemical and physical properties, which can be exploited in many and different biological fields. Fullerene is able to fit inside the hydrophobic cavity of HIV proteases, inhibiting the access of substrates to the catalytic site of the enzyme. It can be used as radical scavenger; in fact some water-soluble derivatives are able to reduce ROS concentrations. At the same time, if exposed to light, fullerene can produce singlet oxygen in high quantum yields. This action, together with the direct electron transfer from excited state of fullerene and DNA bases, can be used to cleave DNA. In this review we report the most recent aspects of fullerene biological applications.
Authors:
Susanna Bosi; Tatiana Da Ros; Giampiero Spalluto; Maurizio Prato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  38     ISSN:  0223-5234     ISO Abbreviation:  Eur J Med Chem     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  France    
Other Details:
Languages:  eng     Pagination:  913-23     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / chemistry,  pharmacology,  therapeutic use
Apoptosis / drug effects,  physiology
Fullerenes / chemistry*,  pharmacology,  therapeutic use*
Humans
Osteoporosis / drug therapy
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Fullerenes; 99685-96-8/fullerene C60

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