Document Detail


Full life-cycle toxicity assessment using rotifer resting egg production: implications for ecological risk assessment.
MedLine Citation:
PMID:  11584638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The majority of standardized toxicity tests incorporate only a fraction of the test organism's life-cycle. However, in natural ecosystems, organisms may be exposed at various times during their life-cycle or throughout their life-cycle. Thus, ecotoxicological data from standardized toxicity tests is of limited ecological relevance. Existing standardized toxicity tests using the freshwater rotifer Brachionus calyciflorus utilize 24-h survival or 48-h asexual reproduction as endpoints, despite evidence that sexual reproduction is more sensitive. A 96-h B. calyciflorus resting egg toxicity test was developed and used to estimate the toxicity of pentachlorophenol (PCP) and copper. Results were compared to a variety of acute and sublethal endpoints for both toxicants. The B. calyciflorus 96-h resting egg production NOEC for PCP of 10 micrograms/l was 20 times lower than the 48-h asexual reproduction no observed effect concentration (NOEC) and 120 times lower than the 24-h acute lethal concentration 50%. The 96-h resting egg production NOEC for copper of 2.8 micrograms/l was 7 times lower than the 48-h asexual reproduction NOEC and nine times lower than the 24-h acute LC50. Resting egg production was a more sensitive indicator of toxicity than several other sublethal endpoints as well. These results indicate that partial life-cycle toxicity tests are not sufficiently sensitive to detect ecologically relevant adverse effects.
Authors:
B L Preston; T W Snell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  114     ISSN:  0269-7491     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-04     Completed Date:  2002-02-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  399-406     Citation Subset:  IM    
Affiliation:
Carolina Environmental Program, Campus Box 1105, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-1105, USA. bpreston@email.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Chlorophenols / toxicity
Copper / toxicity
Dose-Response Relationship, Drug
Ecology
Eggs
Female
Reproduction, Asexual / drug effects*
Risk Assessment
Rotifera / physiology*
Sensitivity and Specificity
Survival Analysis
Time Factors
Toxicity Tests
Chemical
Reg. No./Substance:
0/Chlorophenols; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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