| Full-length genome sequences of five hepatitis C virus isolates representing subtypes 3g, 3h, 3i, and 3k, and a unique genotype 3 variant. | |
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MedLine Citation:
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PMID: 23152370 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We characterized the full-length genomes of five distinct HCV-3 isolates. These represent the first complete genomes for subtypes 3g and 3h, the second such genomes for 3k and 3i, and of one novel variant presently not assigned to a subtype. Each genome was determined from 18-25 overlapping fragments. They had lengths of 9579-9660 nucleotides and each contained a single ORF encoding 3020-3025 amino acids. They were isolated from five patients residing in Canada; four were of Asian origin and one was of Somali origin. Phylogenetic analysis using 64 partial NS5B sequences differentiated 10 assigned subtypes, 3a-3i, 3k, 3l and two additional lineages within genotype 3. From the data of this study, HCV-3 full-length sequences are now available for six of the assigned subtypes and one unassigned. Our findings should add insights to HCV evolutionary studies and clinical applications. |
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Authors:
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Ling Lu; Chunhua Li; Jie Yuan; Teng Lu; Hiroaki Okamoto; Donald G Murphy |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: The Journal of general virology Volume: - ISSN: 1465-2099 ISO Abbreviation: J. Gen. Virol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Kansas Medical Center; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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