Document Detail


Full-length gag sequences of HIV type 1 subtype C recent seroconverters from Pune, India.
MedLine Citation:
PMID:  15585103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although HIV-1 subtype C is the most prevalent subtype worldwide, data on subtype C viruses are rather limited. Very little information is available on the complete HIV-1 subtype C gag sequences from India. We report full-length gag (p55) sequences from six Indian early seroconverters. The samples were collected within few weeks of seroconversion and may represent immunologically naive viruses. The comparison of p55 sequences with other Indian and non-Indian subtype C sequences as well as with nonsubtype C sequences obtained from the Los Alamos database revealed gag as a well-conserved region of the HIV genome (range: 84-95%). The phylogenetic tree indicated that the sequences compared here cluster together within clade C. Two epitopes in the p24 region of the gag gene were subtype C specific while many epitopes in the same region were also present in other clades. The data on HIV-1 subtype C full-length gag sequences would be useful in the design and evaluation of effective subtype C-based HIV vaccines.
Authors:
Swarali Kurle; Srikanth Tripathy; Sushama Jadhav; Kalpana Agnihotri; Ramesh Paranjape
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  20     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1113-8     Citation Subset:  IM; X    
Affiliation:
Department of Molecular Virology, National AIDS Research Institute, Pune, India.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY484419;  AY484420;  AY484421;  AY484422;  AY484423;  AY484424
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
Female
Gene Products, gag / chemistry*,  genetics*
HIV Seropositivity / epidemiology,  virology*
HIV-1 / genetics*,  isolation & purification
Humans
India / epidemiology
Male
Molecular Sequence Data
Phylogeny
Protein Precursors / chemistry,  genetics
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
0/Gene Products, gag; 0/Protein Precursors; 0/p55 gag precursor protein, Human immunodeficiency virus 1

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