| Full Penetrance of Morgagni-Stewart-Morel Syndrome in a 75-Year-Old Woman: Case Report and Review of the Literature. | |
| | |
MedLine Citation:
|
PMID: 23284007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Context:Morgagni-Stewart-Morel syndrome is defined as the presence of hyperostosis frontalis interna, variably associated with metabolic, endocrine, and neuropsychiatric disorders. The possible cause-effect relationship of these associations remains uncertain.Case Presentation:A 75-year-old woman presented with severe frontal headache and a history of psychotic disorders. On instrumental examination she was found to have extensive frontal hyperostosis and cortical atrophy. These findings, associated to the metabolic and neuropsychiatric pattern of the patient, are consistent with a high penetrance of Morgagni-Stewart-Morel syndrome.Evidence Acquisition and Synthesis:In this clinical case seminar, we summarize the current understanding of the association between hyperostosis frontalis interna and Morgagni-Stewart-Morel, based on a MEDLINE search (case reports, original articles, and reviews published between 1928 and 2011) on this topic. Possible pathophysiological mechanisms underlying both the headache and the hyperostosis frontalis interna are discussed.Conclusion:A case of full penetrance of Morgagni-Stewart-Morel syndrome is reported, presenting many of the clinical features described in the literature. Metabolic and endocrine dysfunctions should be interpreted not only as isolated components of the syndrome, but also as the reason behind its pathogenesis. Endocrine or nutritional disorders may have led to an altered bone metabolism with frontal bone apposition. On the other hand, the severity of our patient's neurological and psychiatric symptoms correlates well with the severity of her hyperostosis frontalis interna and the cortical atrophy. |
| | |
Authors:
|
Francesca Attanasio; Serena Granziera; Valter Giantin; Enzo Manzato |
Related Documents
:
|
16011437 - Shiga-toxigenic escherichia coli o157:h7 infections among livestock exhibitors and visi... 16358557 - Delayed postpartum hemorrhage--a rare clinical presentation of thrombotic thrombocytope... 22734557 - Analysis of regulatory review times of new drugs in japan: association with characteris... 7193267 - Autoimmune thrombocytopenic purpura-like syndrome in a patient with head and neck cancer. 19533787 - Poland syndrome with bilateral features: case description with review of the literature. 11922237 - Quadriplegia complicating ossification of the posterior longitudinal ligament. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-2 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Geriatric Unit, Department of Medicine, Padova University, 35100 Padova, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Growth Hormone Therapy for Children and Adolescents with Prader-Willi Syndrome Is Associated with Im...
Next Document: Visceral Fat Accumulation During Lipid Overfeeding Is Related to Subcutaneous Adipose Tissue Charact...