Document Detail


Fuel homeostasis in the harbor seal during submerged swimming.
MedLine Citation:
PMID:  2045543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The turnover rates and oxidation rates of plasma glucose, lactate, and free fatty acids (FFA) were measured in three harbor seals (average mass = 40 kg) at rest or during voluntary submerged swimming in a water flume at 35% (1.3 m.s-1) and 50% (2 m.s-1) of maximum oxygen consumption (MO2max). 2. For seals resting in water, the total turnover rates for glucose, lactate, and FFA were 23.2, 26.2, and 7.5 mumols.min-1.kg-1, respectively. Direct oxidation of these metabolites accounted for approximately 7%, 27%, and 33% of their turnover and 3%, 7%, and 18% of the total ATP production, respectively. 3. For swimming seals, MO2max was achieved at a drag load equivalent to a speed of 3 m.s-1 and averaged 1.85 mmol O2.min-1.kg-1, which is 9-fold greater than resting metabolism in water at 18 degrees C. 4. At 35% and 50% MO2max, glucose turnover and oxidation rates did not change from resting levels. Glucose oxidation contributed about 1% of the total ATP production during swimming. 5. At 50% MO2max, lactate turnover and anaerobic ATP production doubled, but the steady state plasma lactate concentration remained low at 1.1 mM. Lactate oxidation increased 63% but still contributed only 4% of the total ATP production. Anaerobic metabolism contributed about 1% of the total ATP production at rest and during swimming. 6. The plasma FFA concentration and turnover rate increased only 24% and 37% over resting levels, respectively, at 50% MO2max. However, the oxidation rate increased almost 3.5-fold and accounted for 85% of the turnover.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R W Davis; M A Castellini; T M Williams; G L Kooyman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology     Volume:  160     ISSN:  0174-1578     ISO Abbreviation:  J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-15     Completed Date:  1991-07-15     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8413200     Medline TA:  J Comp Physiol B     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  627-35     Citation Subset:  IM; S    
Affiliation:
Physiological Research Laboratory, Scripps Institution of Oceanography, La Jolla, CA 92037.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / biosynthesis
Aerobiosis
Animals
Blood Glucose / metabolism
Diving
Energy Metabolism*
Fatty Acids, Nonesterified / blood
Homeostasis
Immersion / physiopathology
Lactates / blood
Lactic Acid
Male
Oxygen Consumption
Seals, Earless / metabolism*
Swimming*
Grant Support
ID/Acronym/Agency:
HL17731/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate

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