Document Detail

Fuel ethanol production from lignocellulose: a challenge for metabolic engineering and process integration.
MedLine Citation:
PMID:  11499926     Owner:  NLM     Status:  MEDLINE    
With industrial development growing rapidly, there is a need for environmentally sustainable energy sources. Bioethanol (ethanol from biomass) is an attractive, sustainable energy source to fuel transportation. Based on the premise that fuel bioethanol can contribute to a cleaner environment and with the implementation of environmental protection laws in many countries, demand for this fuel is increasing. Efficient ethanol production processes and cheap substrates are needed. Current ethanol production processes using crops such as sugar cane and corn are well-established; however, utilization of a cheaper substrate such as lignocellulose could make bioethanol more competitive with fossil fuel. The processing and utilization of this substrate is complex, differing in many aspects from crop-based ethanol production. One important requirement is an efficient microorganism able to ferment a variety of sugars (pentoses, and hexoses) as well as to tolerate stress conditions. Through metabolic engineering, bacterial and yeast strains have been constructed which feature traits that are advantageous for ethanol production using lignocellulose sugars. After several rounds of modification/evaluation/modification, three main microbial platforms, Saccharomyces cerevisiae, Zymomonas mobilis, and Escherichia coli, have emerged and they have performed well in pilot studies. While there are ongoing efforts to further enhance their properties, improvement of the fermentation process is just one of several factors-that needs to be fully optimized and integrated to generate a competitive lignocellulose ethanol plant.
J Zaldivar; J Nielsen; L Olsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  56     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-13     Completed Date:  2001-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  17-34     Citation Subset:  IM    
Center for Process Biotechnology, Department of Biotechnology, Technical University of Denmark, Lyngby.
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MeSH Terms
Carbohydrate Metabolism
Cellulose / metabolism*
Ethanol / metabolism*
Lignin / metabolism*
Reg. No./Substance:
0/Gasoline; 11132-73-3/lignocellulose; 64-17-5/Ethanol; 9004-34-6/Cellulose; 9005-53-2/Lignin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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