| Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J mice. | |
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MedLine Citation:
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PMID: 20845386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An ethanol extract of fucoxanthin-rich seaweed was examined for its effectiveness as a nutraceutical for body fat-lowering agent and for an antiobese effect based on mode of actions in C57BL/6J mice. Animals were randomized to receive a semi-purified high-fat diet (20% dietary fat, 10% corn oil and 10% lard) supplemented with 0.2% conjugated linoleic acid (CLA) as the positive control, 1.43% or 5.72% fucoxanthin-rich seaweed ethanol extract (Fx-SEE), equivalent to 0.05% or 0.2% dietary fucoxanthin for six weeks. Results showed that supplementation with both doses of Fx-SEE significantly reduced body and abdominal white adipose tissue (WAT) weights, plasma and hepatic triglyceride (TG), and/or cholesterol concentrations compared to the high-fat control group. Activities of adipocytic fatty acid (FA) synthesis, hepatic FA and TG synthesis, and cholesterol-regulating enzyme were also lowered by Fx-SEE supplement. Concentrations of plasma high-density lipoprotein-cholesterol, fecal TG and cholesterol, as well as FA oxidation enzyme activity and UCP1 mRNA expression in epididymal WAT were significantly higher in the Fx-SEE groups than in the high-fat control group. CLA treatment reduced the body weight gain and plasma TG concentration. Overall, these results indicate that Fx-SEE affects the plasma and hepatic lipid profile, fecal lipids and body fat mass, and alters hepatic cholesterol metabolism, FA synthesis and lipid absorption. |
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Authors:
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Seon-Min Jeon; Hye-Jin Kim; Myoung-Nam Woo; Mi-Kyung Lee; Young Chul Shin; Yong Bok Park; Myung-Sook Choi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biotechnology journal Volume: 5 ISSN: 1860-7314 ISO Abbreviation: Biotechnol J Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265833 Medline TA: Biotechnol J Country: Germany |
Other Details:
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Languages: eng Pagination: 961-9 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Obesity Agents / pharmacology Body Weight Cholesterol / blood Dietary Fats / administration & dosage, metabolism Dietary Supplements Lipid Metabolism* Lipids / blood Male Mice Mice, Inbred C57BL Obesity / metabolism, therapy Plant Extracts / isolation & purification*, pharmacology Seaweed / metabolism* Weight Gain Xanthophylls / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Dietary Fats; 0/Lipids; 0/Plant Extracts; 0/Xanthophylls; 3351-86-8/fucoxanthin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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