| Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas. | |
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MedLine Citation:
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PMID: 21078541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin's lymphoma caused by human herpesvirus 8. Conventional chemotherapy has limited effect on PEL, and the prognosis is poor. Carotenoids are a family of natural pigments and have several biological functions. We evaluated the anti-PEL effects of carotenoid, fucoxanthin (FX) and its metabolite, fucoxanthinol (FXOH). Treatment of PEL cells with FX or FXOH induced cell cycle arrest during G₁ phase and caspase-dependent apoptosis. FX and FXOH treatment silenced NF-κB, AP-1 and Akt activation, in conjunction with down-regulation of anti-apoptotic proteins and cell cycle regulators. Importantly, proteasome degradation was responsible for the low levels of proteins after FXOH treatment. In animal studies, treatment with FX reduced the growth of PEL-cell tumors. The results provide the rationale for future clinical use of FX and FXOH for the treatment of PEL. |
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Authors:
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Kei Yamamoto; Chie Ishikawa; Harukata Katano; Takeshi Yasumoto; Naoki Mori |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 300 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-11-30 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 225-34 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Microbiology and Oncology, University of the Ryukyus, Nishihara, Okinawa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Apoptosis / drug effects* Blotting, Western Caspases / drug effects, metabolism Cell Cycle / drug effects Cell Line, Tumor Cell Survival / drug effects Electrophoretic Mobility Shift Assay Humans Lymphoma, Primary Effusion* / metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / drug effects Xanthophylls / pharmacology* beta Carotene / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Xanthophylls; 3351-86-8/fucoxanthin; 7176-02-5/fucoxanthinol; 7235-40-7/beta Carotene; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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