Document Detail


Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study.
MedLine Citation:
PMID:  17383304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
METHODS: We used data on 1735 unrelated subjects in the Framingham Offspring Study to assess whether 3 functional single-nucleotide polymorphisms (SNPs) of the FUT3 gene (T59G, T1067A, and T202C) were associated with prevalent atherothrombotic disease.
RESULTS: Contrary to T1067A and T202C SNPs, there was evidence for an association between T59G SNP and atherothrombotic disease prevalence. In a multivariable model controlling for age, sex, alcohol intake, pack-years of smoking, ratio of total to high-density lipoprotein cholesterol, and diabetes mellitus, ORs (95% CI) for prevalent atherothrombotic disease were 1.0 (reference), 0.80 (0.46-1.41), and 6.70 (1.95-23.01) for TT, TG, and GG genotypes of the T59G SNP, respectively. Minor alleles of T202C and T1067A SNPs showed a modest and nonsignificant association with atherothrombotic disease. Overall, FUT3 polymorphism that influences the enzyme activity (GG genotype for T59G or > or = 1 minor allele of T202C or T1067A) was associated with increased atherothrombotic disease prevalence (OR 1.57, 1.05-2.34), and this association was stronger among abstainers (2-fold increased odds) than among current drinkers (P for interaction .11).
CONCLUSIONS: Our data suggest that functional mutations of the FUT3 gene may be associated with an increased atherothrombotic disease prevalence, especially among abstainers. Additional studies are warranted to confirm these findings.
Authors:
Luc Djoussé; Samer Karamohamed; Alan G Herbert; Ralph B D'Agostino; L Adrienne Cupples; R Curtis Ellison
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American heart journal     Volume:  153     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-05-03     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  636-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / genetics*
Cohort Studies
Coronary Disease / genetics*
Female
Fucosyltransferases / genetics*
Humans
Male
Middle Aged
Polymorphism, Genetic*
Thrombosis / genetics*
Grant Support
ID/Acronym/Agency:
5K01 HL070444/HL/NHLBI NIH HHS; K01 HL070444/HL/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 2.4.1.-/Fucosyltransferases; EC 2.4.1.152/galactoside 3-fucosyltransferase
Comments/Corrections
Erratum In:
Am Heart J. 2007 Jul;154(1):11

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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