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Fucose and sialic acid expressions in human seminal fibronectin and α{1} -acid glycoprotein associated with leukocytospermia of infertile men.
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MedLine Citation:
PMID:  22048274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The aim of this study was to compare fucose and sialic acid residue expression on fibronectin and α{1}-acid glycoprotein in the seminal plasma of men suspected of infertility and suffering from leukocytospermia.
SUBJECTS AND METHODS: Seminal ejaculates were collected from 27 leukocytospermic and 18 healthy, normozoospermic men. The relative degree of fucosylation and sialylation of fibronectin and α{1}-acid glycoprotein was estimated by ELISA using fucose and sialic acid specific lectins from Aleuria aurantia, Lotus tetragonolobus, and Ulex europaeus as well as Maackia amurensis and Sambucus nigra, respectively.
RESULTS: Leukocytospermic seminal fibronectin, in comparison with fibronectin of normal fertile group, showed lower relative reactivity with AAL, LTA and UEA, and higher reactivity with MAA and SNA, while the AGP of the leukocytospermic group was less reactive with AAL, and the relative reactivity with LTA and MAA was significantly higher. Fibronectin and α{1}-acid glycoprotein reactivity with UEA and MAA showed high positive correlations.
DISCUSSION: Leukocytospermia was associated with the alterations of terminal monosaccharide expression in human seminal fibronectin and α{1}-acid glycoprotein. The increase of sialyl-Lewis{ x} antigen in α{1}-acid glycoprotein can be used as a marker of genital tract inflammation manifested by leukocytospermia.
Authors:
Ewa M Kratz; Ricardo Faundez; Iwona Katnik-Prastowska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Disease markers     Volume:  31     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-03     Completed Date:  2012-02-22     Revised Date:  2013-12-02    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  317-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Enzyme-Linked Immunosorbent Assay / methods
Fibronectins / metabolism*
Fucose / chemistry,  metabolism*
Glycosylation
Humans
Infertility, Male / metabolism*,  pathology
Lectins / chemistry
Leukocytes / pathology
Male
Middle Aged
N-Acetylneuraminic Acid / chemistry,  metabolism*
Orosomucoid / metabolism*
Protein Processing, Post-Translational*
Semen / metabolism*
Sperm Count
Young Adult
Chemical
Reg. No./Substance:
0/Fibronectins; 0/Lectins; 0/Orosomucoid; 3713-31-3/Fucose; GZP2782OP0/N-Acetylneuraminic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2011 Hindawi Publishing Corporation.
Received Day: 14 Month: 10 Year: 2011
Accepted Day: 14 Month: 10 Year: 2011
Print publication date: Year: 2011
Electronic publication date: Day: 1 Month: 11 Year: 2011
Volume: 31 Issue: 5
First Page: 317 Last Page: 325
PubMed Id: 22048274
ID: 3826480
Article Id: 914710
DOI: 10.3233/DMA-2011-0846

Fucose and Sialic Acid Expressions in Human Seminal Fibronectin and α1-Acid Glycoprotein Associated with Leukocytospermia of Infertile Men
Ewa M. Kratz1*
Ricardo Faundez2
Iwona Kątnik-Prastowska1
1Department of Chemistry and ImmunochemistryWrocław Medical UniversityBujwida 44aWrocławPoland
2Embryology Laboratory InviMed – European Center of MotherhoodRakowiecka 3602-532 WarsawPolandand Warsaw University of Life Sciences Faculty of Veterinary Medicine Department of Large Animal Diseases and Clinic Division of Animal ReproductionAndrology and Biotechnology of ReproductionNowoursynowska 100Warszawa – WolicaPoland
Correspondence: *Ewa M. Kratz: kratz@immchem.am.wroc.pl


Article Categories:
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Keywords: Fibronectin, α1-acid glycoprotein, fucosylation, sialylation, leukocytospermic human seminal plasma.

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