| Fruit and vegetable intake and the risk of gastric adenocarcinoma: a re-analysis of the European prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up. | |
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MedLine Citation:
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PMID: 22473701 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In a previous EPIC analysis we found an inverse association between total intake of vegetables and onion and garlic and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to re-analyse the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the number of GC cases. Subjects are 477,312 men and women mostly aged 35 to 70 years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11 years of follow-up. Information on diet and lifestyle was collected at baseline. A calibration study in a sub-sample was used to correct for dietary measurement errors. Comparing the highest vs lowest quintile of intake, we found an inverse association between total intake of V&F and GC risk (HR 0.77; 95% CI 0.57-1.04; p for trend 0.02), between fresh fruit and risk of the diffuse type (HR 0.59; 95% CI 0.36-0.97; p for trend 0.03), and an inverse association between citrus fruit and risk of cardia cancer (HR 0.61; 95% CI 0.38-1.00, p for trend 0.01). Although calibration revealed somewhat stronger inverse associations none of the risks reached statistical significance. There was no association between total or specific vegetables intake and GC risk. The inverse association between fresh fruit and citrus fruits and risk of GC seems to be restricted to smokers and the Northern European countries. Fresh fruit and citrus fruit consumption may protect against diffuse and cardia GC respectively. © 2012 Wiley-Liss, Inc. |
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Authors:
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Carlos A Gonzalez; Leila Lujan-Barroso; H Bas Bueno de Mesquita; Mazda Jenab; Eric J Duell; Antonio Agudo; Anne Tjønneland; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Marina Touillaud; Birgit Teucher; Rudolf Kaaks; Heiner Boeing; Annika Steffen; Antonia Trichopoulou; Dimitrios Roukos; Tina Karapetyan; Domenico Palli; Giovanna Tagliabue; Amalia Mattiello; Rosario Tumino; Fulvio Ricceri; Peter D Siersema; Mattijs E Numans; Petra Ph Peeters; Christine L Parr; Guri Skeie; Eiliv Lund; J Ramón Quirós; Emilio Sánchez-Cantalejo; Carmen Navarro; Aurelio Barricarte; Miren Dorronsoro; Roy Ehrnström; Sara Regner; Kay-Tee Khaw; Nick Wareham; Timothy J Key; Francesca L Crowe; Hendrik Blaker; Isabelle Romieu; Elio Riboli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-2 |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: - ISSN: 1097-0215 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 UICC. |
Affiliation:
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Unit of Nutrition, Environment and Cancer. Programme of Epidemiological Research, Catalan Institute of Oncology, Barcelona (ICO-IDIBELL), Spain. cagonzalez@iconcologia.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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