Document Detail


Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men.
MedLine Citation:
PMID:  17284753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nutrients with antioxidant properties or that influence cell growth and differentiation might reduce the risk of benign prostatic hyperplasia (BPH). OBJECTIVE: The objective was to evaluate the association of fruit, vegetable, and micronutrient intakes with BPH. DESIGN: The participants were members of the Health Professionals Follow-Up Study and were aged 46-81 y in 1992. In 1992 and biennially thereafter, the men reported having surgery for an enlarged prostate, and in 1992 and on 3 subsequent questionnaires they completed the American Urological Association symptom index (AUASI). BPH cases were men who reported having surgery or who had an AUASI score of 15-35 (n = 6092). Control subjects were men who had not had surgery and never had an AUASI score >7 (n = 18 373). Men with a score of 8-14 were excluded (n = 7800). Intakes of fruit, vegetables, and antioxidants were assessed with a food-frequency questionnaire in 1986. We calculated odds ratios (ORs) of BPH and 95% CIs using logistic regression. RESULTS: Vegetable consumption was inversely associated with BPH (fifth compared with first quintile-OR: 0.89; 95% CI: 0.80, 0.99; P for trend = 0.03), whereas fruit intake was not. Consumption of fruit and vegetables rich in beta-carotene (P for trend = 0.004), lutein (P for trend = 0.0004), or vitamin C (P for trend = 0.05) was inversely related to BPH. With increasing vitamin C intake from foods, men were less likely to have BPH (P for trend = 0.0009). Neither alpha- nor gamma-tocopherol intake from foods was associated with BPH (P for trend = 0.05 and 0.84, respectively). CONCLUSION: Our findings are consistent with the hypothesis that a diet rich in vegetables may reduce the occurrence of BPH.
Authors:
Sabine Rohrmann; Edward Giovannucci; Walter C Willett; Elizabeth A Platz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  85     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-03-13     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Fruit*
Humans
Male
Micronutrients / administration & dosage*,  pharmacology*
Middle Aged
Odds Ratio
Prostatic Hyperplasia / epidemiology*,  prevention & control*
Risk Factors
United States / epidemiology
Vegetables*
Grant Support
ID/Acronym/Agency:
CA55075/CA/NCI NIH HHS; DK44779/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Micronutrients

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