Document Detail


Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion-Transporting Polypeptides.
MedLine Citation:
PMID:  23033114     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Grapefruit juice is widely recognized to cause important drug interactions via inhibition of CYP3A4, and a wider variety of fruit juices have been shown to inhibit influx transporters in enterocytes known as organic anion-transporting polypeptides (OATPs). Fruit juice coadministration significantly reduces the oral bioavailability of numerous important medicines relying on this anion transporter pathway for absorption. This article reviews the current literature on interactions between clinically used OATP substrates and fruit juice consumption.Clinical Pharmacology & Therapeutics (2012); advance online publication 3 October 2012. doi:10.1038/clpt.2012.159.
Authors:
M J Dolton; B D Roufogalis; A J McLachlan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-03
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  -     ISSN:  1532-6535     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Pharmacy, University of Sydney, Sydney, Australia.
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