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Fructose protects baker's yeast against peroxide stress: potential role of catalase and superoxide dismutase.
MedLine Citation:
PMID:  22741594     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The negative effects of fructose due to its chronic consumption are well documented, while short-term application of fructose is found to protect different types of cells against oxidative stress. ROS are suggested to mediate both the cytotoxic and defensive effects. Here, we compare the influence of glucose and fructose on yeast under H(2) O(2) -induced stress. Under control conditions, fructose-grown comparing to glucose-grown yeast demonstrated higher metabolic activity and ROS level. Therefore, fructose was suggested to provoke a mild stress resulted in the acquisition of cellular resistance to lethal challenges that explained higher survival of fructose-grown yeast under H(2) O(2) -induced shock. Exposure to H(2) O(2) increased ROS level in glucose-grown cells, whereas decreased it in fructose-grown cells. Hydrogen peroxide activated SOD and catalase in both the studied cell types, but glucose-grown cells demonstrated a sharp rise of the activities, while cells grown on fructose showed a broad peak of activation. Thus, fructose is likely to protect the antioxidant enzymes against their inactivation by H(2) O(2) . Despite different character of the enzyme activation in both the studied cell types (glucose- and fructose grown), strong positive correlation between SOD and catalase was found. Physiological meaning of this relationship and possible mechanism of fructose protective effect are discussed. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Authors:
Halyna M Semchyshyn; Liudmyla M Lozinska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-29
Journal Detail:
Title:  FEMS yeast research     Volume:  -     ISSN:  1567-1364     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101085384     Medline TA:  FEMS Yeast Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Affiliation:
Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, 57 Shevchenko Str., 76025, Ivano-Frankivsk, Ukraine.
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