Document Detail

Fructose-induced breath hydrogen in patients with fruit intolerance.
MedLine Citation:
PMID:  18209585     Owner:  NLM     Status:  MEDLINE    
GOALS: To measure bloating score, flatus passage, and hydrogen production after oral fructose in patients with history of fruit intolerance and compare these parameters with those in normal controls. BACKGROUND: Some patients complain of abdominal distention and excessive flatus after ingesting certain fruits such as mango, persimmon, and grapes but not after eating apricots and melon. STUDY: We recorded breath hydrogen, flatus passage and bloating after 20 g fructose in 8 patients with history of fruit intolerance and 4 healthy controls. Breath hydrogen was measured every 15 minutes for 480 minutes using EC-60 gastrolyzer. Number of passage of flatus was recorded over 8 hours. Severity of abdominal distention on a scale of 1 to 10 was noted. RESULTS: The patients with fruit intolerance produced breath hydrogen 1745.2+/-7.8 parts per million, passed flatus 13.8+/-0.3 times, and had bloating score of 5.7+/-0.1. The healthy controls produced breath hydrogen 712.5+/-5.8 parts per million in 8 hours, passed flatus 7.2+/-0.5 time, and had bloating score of 2.7+/-0.2. CONCLUSIONS: After 20 g fructose, patients with history of fruit intolerance produce more breath hydrogen, pass flatus more frequently, and have a higher bloating score compared with healthy controls.
Nirmal S Mann; Eddie C Cheung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  42     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-22     Completed Date:  2008-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-9     Citation Subset:  IM    
Division of Gastroenterology, Davis School of Medicine, University of California, USA.
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MeSH Terms
Breath Tests / methods*
Dyspepsia / etiology*,  physiopathology*
Flatulence / etiology
Fructose / metabolism*
Fruit / adverse effects*,  metabolism
Hydrogen / metabolism*
Middle Aged
Severity of Illness Index
Reg. No./Substance:
1333-74-0/Hydrogen; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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