| Fructose in fetal cord blood and its relationship with maternal and 48-hour-newborn blood concentrations. | |
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MedLine Citation:
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PMID: 21276669 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Studies have suggested that different non-glucose sugars and sugar alcohols play a role in placental and fetal metabolism. However, the role of fructose in the fetal and newborn metabolism is unclear and studies are scarce. AIM: Our objective was to investigate the presence of fructose in umbilical cord blood in full-term gestation and its relationship with maternal and 48-hour-old- newborn blood concentrations, to evaluate fructose production by the fetus and newborn infant. METHODS: Blood fructose and glucose concentrations were determined by HPLC in 26 paired samples of maternal blood, umbilical cord vein, and peripheral newborn blood at 48h after birth. ANOVA, the Friedman Analysis of Variance on Ranks and the Pearson correlation with p<0.05 were used. RESULTS: Fructose concentration in umbilical cord blood was higher than maternal blood (p=0.024), suggesting endogenous fructose production by the fetal-placental unit via the sorbitol pathway. Fructose concentrations were higher in newborns at 48h after birth than in the fetal umbilical cord blood (p=0.004), suggesting that fructose production is a continuous process from fetus to newborn. CONCLUSIONS: Fructose production by the sorbitol pathway, present in the fetus and newborn, is an alternative pathway in glucose metabolism probably used to maintain redox balance in the fetus. We suggest that endogenous fructose, similar to dietary ingested fructose, under physiological conditions produces the backbone for triacylglycerol and lipid synthesis in the fetus and newborn. Therefore the route for metabolizing fructose is already present in the early steps of human development. |
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Authors:
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Cleide E P Trindade; Rodrigo C Barreiros; Cilmery Kurokawa; Grasiela Bossolan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-26 |
Journal Detail:
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Title: Early human development Volume: - ISSN: 1872-6232 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, Division of Neonatology, Botucatu School of Medicine, UNESP São Paulo State University-Botucatu, São Paulo 18618-970, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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