| Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose. | |
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MedLine Citation:
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PMID: 20826630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: When fructose is ingested together with glucose (GLUFRU) during exercise, plasma lactate and exogenous carbohydrate oxidation rates are higher than with glucose alone. OBJECTIVE: The objective was to investigate to what extent GLUFRU increased lactate kinetics and oxidation rate and gluconeogenesis from lactate (GNG(L)) and from fructose (GNG(F)). DESIGN: Seven endurance-trained men performed 120 min of exercise at ≈60% VO₂max (maximal oxygen consumption) while ingesting 1.2 g glucose/min + 0.8 g of either glucose or fructose/min (GLUFRU). In 2 trials, the effects of glucose and GLUFRU on lactate and glucose kinetics were investigated with glucose and lactate tracers. In a third trial, labeled fructose was added to GLUFRU to assess fructose disposal. RESULTS: In GLUFRU, lactate appearance (120 ± 6 μmol · kg⁻¹ · min⁻¹), lactate disappearance (121 ± 7 μmol · kg⁻¹ · min⁻¹), and oxidation (127 ± 12 μmol · kg⁻¹ · min⁻¹) rates increased significantly (P < 0.001) in comparison with glucose alone (94 ± 16, 95 ± 16, and 97 ± 16 μmol · kg⁻¹ · min⁻¹, respectively). GNG(L) was negligible in both conditions. In GLUFRU, GNG(F) and exogenous fructose oxidation increased with time and leveled off at 18.8 ± 3.7 and 38 ± 4 μmol · kg⁻¹ · min⁻¹, respectively, at 100 min. Plasma glucose appearance rate was significantly higher (P < 0.01) in GLUFRU (91 ± 6 μmol · kg⁻¹ · min⁻¹) than in glucose alone (82 ± 9 μmol · kg⁻¹ · min⁻¹). Carbohydrate oxidation rate was higher (P < 0.05) in GLUFRU. CONCLUSIONS: Fructose increased total carbohydrate oxidation, lactate production and oxidation, and GNG(F). Fructose oxidation was explained equally by fructose-derived lactate and glucose oxidation, most likely in skeletal and cardiac muscle. This trial was registered at clinicaltrials.gov as NCT01128647. |
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Authors:
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Virgile Lecoultre; Rachel Benoit; Guillaume Carrel; Yves Schutz; Grégoire P Millet; Luc Tappy; Philippe Schneiter |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-09-08 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1071-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01128647 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism* Cross-Over Studies Exercise / physiology* Fructose / metabolism, pharmacology* Gluconeogenesis / drug effects* Glucose / metabolism, pharmacology* Humans Lactic Acid / metabolism* Male Oxidation-Reduction Oxygen Consumption Single-Blind Method |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 30237-26-4/Fructose; 50-21-5/Lactic Acid; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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