Document Detail

Fructose feeding and intermittent hypoxia affect ventilatory responsiveness to hypoxia and hypercapnia in rats.
MedLine Citation:
PMID:  15194673     Owner:  NLM     Status:  MEDLINE    
We hypothesized that, in male rats, 10% fructose in drinking water would depress ventilatory responsiveness to acute hypoxia (10% O2 in N2) and hypercapnia (5% CO2 in O2) that would be depressed further by exposure to intermittent hypoxia. Minute ventilation (Ve) in air and in response to acute hypoxia and hypercapnia was evaluated in 10 rats before fructose feeding (FF), during 6 wk of FF, and after FF was removed for 2 wk. During FF, five rats were exposed to intermittent air and five to intermittent hypoxia for 13 days. Six rats given tap water acted as control and were exposed to intermittent air and subsequently intermittent hypoxia. In FF rats, plasma insulin levels increased threefold in the rats exposed to intermittent hypoxia and during washout returned to levels observed in rats exposed to intermittent air. During FF, ventilatory responsiveness to acute hypoxia was depressed because of decreased tidal volume (Vt) responsiveness. During washout, Ve decreased as a result of decreased Vt and frequency of breathing, and the ventilatory responsiveness to hypoxia in intermittent hypoxia rats did not recover. In all rats, the ventilatory responses to hypercapnia were decreased during FF and recovered after washout because of an increased Vt responsiveness. In the control group, hypoxic responsiveness was not depressed after intermittent hypoxia and was augmented after washout. Thus FF attenuated the ventilatory responsiveness of conscious rats to hypoxia and hypercapnia. Intermittent hypoxia interacted with FF to increase insulin levels and depress ventilatory responses to acute hypoxia that remained depressed during washout.
Evelyn H Schlenker; Yijiang Shi; Joni Wipf; Douglas S Martin; Curtis K Kost
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-06-11
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  97     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-10     Completed Date:  2005-04-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1387-94     Citation Subset:  IM    
Basic Biomedical Sciences, Univ. of South Dakota School of Medicine, Vermillion, SD 57069, USA.
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MeSH Terms
Adaptation, Physiological / drug effects,  physiology
Administration, Oral
Anoxia / classification,  complications,  physiopathology*
Blood Pressure / drug effects*
Fructose / administration & dosage*
Heart Rate / drug effects*
Hypercapnia / complications,  physiopathology*
Pulmonary Gas Exchange / drug effects*
Pulmonary Ventilation / drug effects*
Rats, Sprague-Dawley
Severity of Illness Index
Grant Support
1 P20 RR-17662/RR/NCRR NIH HHS; P20 RR-15567/RR/NCRR NIH HHS
Reg. No./Substance:

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