Document Detail


Fructose 2,6-bisphosphate in rat skeletal muscle during contraction.
MedLine Citation:
PMID:  6548625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fructose 2,6-bisphosphate and several glycolytic intermediates were measured in two rat muscles, extensor digitorum longus and gastrocnemius, which were electrically stimulated in situ. Both the duration and the frequency of stimulation were varied to obtain different rates of glycolysis. There was no relationship between fructose 2,6-bisphosphate content and the increase in tissue lactate in contracting muscle. However, in gastrocnemius stimulated at low frequencies (less than or equal to 5 Hz), there was a 2-fold increase in fructose 2,6-bisphosphate at 10s, followed by a return to basal values, whereas lactate increased only after 1 min of contraction. The concentrations of hexose 6-phosphates, fructose 1,6-bisphosphate and triose phosphates were all increased during the 3 min stimulation. During tetanus (frequencies greater than or equal to 10 Hz) fructose 2,6-bisphosphate was not increased, whereas glycolysis was maximally stimulated and resulted in an accumulation of tissue lactate, mostly from glycogen. The concentrations of hexose 6-phosphate increased continuously during the 1 min tetanus, whereas fructose 1,6-bisphosphate was increased at 10s and then decreased progressively. It therefore appears that fructose 2,6-bisphosphate does not play a role in the stimulation of glycolysis during tetanus; it may, however, be involved in the control of glycolysis when the muscles are stimulated at low frequencies for short periods of time.
Authors:
Y Minatogawa; L Hue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  223     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-07     Completed Date:  1984-12-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Electric Stimulation
Fructosediphosphates / metabolism*
Glycolysis
Hexosediphosphates / metabolism*
Lactates / metabolism
Lactic Acid
Male
Muscle Contraction*
Muscles / metabolism*
Rats
Rats, Inbred Strains
Time Factors
Chemical
Reg. No./Substance:
0/Fructosediphosphates; 0/Hexosediphosphates; 0/Lactates; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 79082-92-1/fructose 2,6-diphosphate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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