Document Detail

Fructose-1,6-diphosphate as an in vitro and in vivo anti-alcohol agent in the rat.
MedLine Citation:
PMID:  2160337     Owner:  NLM     Status:  MEDLINE    
Fructose-1, 6-diphosphate (FDP) decreases the effect of ethanol on Ca++ entry and inhibits the ethanol-stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol-stimulated [36Cl-]-uptake by rat brain microvesicles and affects the isolated GABA-receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose-dependent decrease in ethanol-induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP.
L Galzigna; M Bianchi; V Rizzoli; R Scuri; P Giannetti; A Paesano
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  8     ISSN:  0263-6484     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-06-28     Completed Date:  1990-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
Department of Biological Chemistry, University of Padova, Italy.
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MeSH Terms
Brain / metabolism
Calcium / metabolism
Chlorides / metabolism
Diuresis / drug effects
Ethanol / antagonists & inhibitors*
Fructosediphosphates / pharmacology*
Hexosediphosphates / pharmacology*
Myocardium / metabolism
Peptic Ulcer / prevention & control
Phosphorus / metabolism
Rats, Inbred Strains
Receptors, GABA-A / drug effects,  metabolism
Substance Withdrawal Syndrome / drug therapy
Transaminases / blood
Reg. No./Substance:
0/Chlorides; 0/Fructosediphosphates; 0/Hexosediphosphates; 0/Receptors, GABA-A; 488-69-7/fructose-1,6-diphosphate; 64-17-5/Ethanol; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC 2.6.1.-/Transaminases

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