| Frozen-thawed embryo transfer cycles: clinical outcomes of single and double blastocyst transfers. | |
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MedLine Citation:
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PMID: 21373800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate clinical outcomes of frozen-thawed embryo transfer cycles when one or two blastocysts are transferred. METHODS: Retrospective chart review RESULTS: Two hundred forty-three frozen blastocyst transfer (FBT) cycles were analyzed. Clinical pregnancy rate (50.4% vs. 34.7%), live birth rate (45.8% vs. 30.6%), and twin live birth rate (19.3% vs. 0) were significantly higher in the double versus single FBT group, respectively (p < 0.05). Prior fresh cycle success with same-cohort embryos did not predict outcome of FBT cycle. When the fresh cycle was unsuccessful, there still was a significant increase in twinning when two frozen-thawed blastocysts were transferred. CONCLUSIONS: Transferring two blastocysts during an FBT cycle resulted in higher live birth and twin live birth rates. Single FBT provided acceptable pregnancy rates for couples seeking to avoid a multiple pregnancy or for those having a single blastocyst stored. Interestingly, the outcome of fresh cycle with same-cohort embryos did not influence the outcome of frozen-thawed cycle. |
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Authors:
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Inna Berin; Sarah T McLellan; Eric A Macklin; Thomas L Toth; Diane L Wright |
Publication Detail:
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Type: Journal Article Date: 2011-03-04 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 28 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-08-26 Completed Date: 2011-12-19 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 575-81 Citation Subset: IM |
Affiliation:
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Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. inna_berin@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Cryopreservation Embryo Implantation* Embryo Transfer / methods* Female Fertilization in Vitro / methods* Humans Pregnancy Pregnancy Outcome Pregnancy Rate Retrospective Studies Twins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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