Document Detail


Frozen-thawed embryo transfer cycles: clinical outcomes of single and double blastocyst transfers.
MedLine Citation:
PMID:  21373800     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate clinical outcomes of frozen-thawed embryo transfer cycles when one or two blastocysts are transferred.
METHODS: Retrospective chart review
RESULTS: Two hundred forty-three frozen blastocyst transfer (FBT) cycles were analyzed. Clinical pregnancy rate (50.4% vs. 34.7%), live birth rate (45.8% vs. 30.6%), and twin live birth rate (19.3% vs. 0) were significantly higher in the double versus single FBT group, respectively (p < 0.05). Prior fresh cycle success with same-cohort embryos did not predict outcome of FBT cycle. When the fresh cycle was unsuccessful, there still was a significant increase in twinning when two frozen-thawed blastocysts were transferred.
CONCLUSIONS: Transferring two blastocysts during an FBT cycle resulted in higher live birth and twin live birth rates. Single FBT provided acceptable pregnancy rates for couples seeking to avoid a multiple pregnancy or for those having a single blastocyst stored. Interestingly, the outcome of fresh cycle with same-cohort embryos did not influence the outcome of frozen-thawed cycle.
Authors:
Inna Berin; Sarah T McLellan; Eric A Macklin; Thomas L Toth; Diane L Wright
Publication Detail:
Type:  Journal Article     Date:  2011-03-04
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  28     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-08-26     Completed Date:  2011-12-19     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  575-81     Citation Subset:  IM    
Affiliation:
Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. inna_berin@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Cryopreservation
Embryo Implantation*
Embryo Transfer / methods*
Female
Fertilization in Vitro / methods*
Humans
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Retrospective Studies
Twins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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