Document Detail

Frontotemporal lobar degeneration (FTLD) -changes of its concept and classification based on aggregated proteins.
MedLine Citation:
PMID:  23196569     Owner:  NLM     Status:  In-Data-Review    
FTLD is a purely anatomically defined concept, being unrelated to the underling cellular pathology; the sine qua non is only the presence of main lesions in the frontal and temporal lobes. FTLD, therefore, is destined to include various maladies that involve the two areas. Cases reported by Arnold Pick, "Pick's disease", are a prototype of FTLD. Because of lack of histopathological description of the brains in his reports, however, the nomenclature brought about a great confusion in its nosology; the history of establishing the concept of FTLD was that of how to seperate genuine Pick's disease. After a long chaos, the present molecular neuropathology has ultimately resolved this problem by clarifying protein constituents of neuronal and glial aggregates in FTLD. TDP-43 was first found in ALS and ALS with dementia (ALSD), and soon FUS/TLS was detected in some TDP-43-negative FTLD-U groups. At the present time, FTLD consists of three main subgroups; 1) FTLD-tau, which includes Pick disease, PSP, CBD, etc., 2) FTLD-TDP, which is subdivided into types A-D, with ALSD belonging to type B, and 3) FTLD-FUS, the members of which are aFTLD-U, NIFID, and BIBD. Further discovery of yet-undetected proteins of some FTLD-U subsets will add more subclasses.
Imaharu Nakano
Related Documents :
22826719 - Hailey-hailey disease treated with methotrexate.
24555239 - Diffusion mri measured white matter microstructure as a biomarker of neurodegeneration ...
24516819 - Wisdom teeth extraction in a patient with moyamoya disease.
23375669 - Vestibular loss as a contributor to alzheimer's disease.
23643869 - Impact of maedi-visna in intensively managed dairy sheep.
24300789 - Ocular motor disorders.
20590559 - The endocannabinoid system as a target for the treatment of neurodegenerative disease.
24949459 - Periodontal pathogens and atherosclerosis: implications of inflammation and oxidative m...
17288639 - An outbreak of e. coli o157 associated with a swimming pool: an unusual vehicle of tran...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rinshō shinkeigaku = Clinical neurology     Volume:  52     ISSN:  1882-0654     ISO Abbreviation:  Rinsho Shinkeigaku     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417466     Medline TA:  Rinsho Shinkeigaku     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1218-20     Citation Subset:  IM    
Division of Neurology, Department of Medicine, Jichi Medical University School of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical translation of hepatocyte growth factor for amyotrophic lateral sclerosis.
Next Document:  Conjoint pathological cascades mediated by RNA-binding proteins, TDP-43, FUS and Ataxin-2.