Document Detail

Frontotemporal dementia presenting as schizophrenia-like psychosis in young people: clinicopathological series and review of cases.
MedLine Citation:
PMID:  19336778     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Few studies have investigated the relationship between schizophrenia and frontotemporal dementia. AIMS: To investigate this relationship through a clinicopathological investigation of young-onset frontotemporal dementia and a review of the case literature. METHOD: Cases of young-onset frontotemporal dementia were identified within the local brain bank. The clinical course and pathological findings were collated. For the literature review, cases of frontotemporal dementia identified through Medline were selected according to defined criteria. The demographic, clinical, pathological and genetic characteristics of cases presenting with a psychotic illness were identified. RESULTS: In the case series, 5 of 17 patients with frontotemporal dementia had presented with a psychotic illness (schizophrenia/schizoaffective disorder n=4, bipolar disorder n=1) an average of 5 years prior to the dementia diagnosis. Patients with schizophrenia exhibited changes consistent with TDP-43 and ubiquitin-positive frontotemporal dementia. In the cases review, a third of patients aged 30 years or under and a quarter of those aged 40 years or under had been diagnosed with psychosis at presentation. CONCLUSIONS: Patients with young-onset frontotemporal dementia may be diagnosed with a psychotic illness years before the dementia diagnosis is made. These findings have implications for clinicians and for our further understanding of the neurobiology of psychotic illness.
D Velakoulis; M Walterfang; R Mocellin; C Pantelis; C McLean
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  194     ISSN:  1472-1465     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-305     Citation Subset:  IM    
Neuropsychiatry Unit, Level 2 John Cade Building, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia.
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MeSH Terms
Age of Onset
DNA-Binding Proteins / genetics
Dementia / diagnosis,  pathology*
Middle Aged
Mutation / genetics
Regression Analysis
Schizophrenia / diagnosis,  pathology*
Young Adult
tau Proteins / metabolism
Reg. No./Substance:
0/DNA-Binding Proteins; 0/protein TDP-43; 0/tau Proteins

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