Document Detail

Frontotemporal dementia and motor neuron disease: report of 3 cases in Taiwan and literature review.
MedLine Citation:
PMID:  22009125     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Case reports and a review of literature of the coexistence of motor neuron disease (MND) and frontotemporal dementia (FTD).
CASE REPORT: All three patients demonstrated generalized lower motor neuron signs and very few upper motor neuron signs. In the level of patterns of cognitive impairments, neuropsychological studies do not distinguish between patients with onset of weakness from bulbar palsy and patients with onset of weakness from limbs. All patients of FTD had their onset of MND or amyotrophic lateral sclerosis symptoms within a two-year interval which is similar to previous reports. FTD combined with MND may shorten the survival to less than three years shorter than cases with FTD only. Respiratory failure occurred one to two years after onset of the behavioral symptoms in all patients.
CONCLUSION: We reported three patients of FTD with MND to remind clinicians that these two disorders may occur together on the same patient and that these two disorders may belong to one broad spectrum neurodegenerative disease.
KEYWORDS: motor neuron disease, amyotrophic lateral sclerosis, frontotemporal dementia, frontotemporal lobar degeneration.
Kai-Hsiang Chen; Ming-Jang Chiu; Ting-Wen Cheng; Jen-Jen Su
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta neurologica Taiwanica     Volume:  20     ISSN:  1028-768X     ISO Abbreviation:  Acta Neurol Taiwan     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-19     Completed Date:  2012-02-28     Revised Date:  2012-11-09    
Medline Journal Info:
Nlm Unique ID:  9815355     Medline TA:  Acta Neurol Taiwan     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  202-8     Citation Subset:  IM    
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
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MeSH Terms
Amyotrophic Lateral Sclerosis / complications
Frontotemporal Dementia / complications*
Middle Aged
Motor Neuron Disease / complications*

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