Document Detail

Frontotemporal dementia: clinical, neuroimaging, and molecular biological findings in 6 patients.
MedLine Citation:
PMID:  11829209     Owner:  NLM     Status:  MEDLINE    
Establishing the diagnosis in patients with clinical signs and symptoms suggesting primary degenerative disease with marked frontal lobe involvement is difficult. Neuroimaging methods, in particular positron emission tomography (PET) with the tracer 18fluoro-2-deoxyglucose (FDG) and cerebrospinal fluid (CSF) examination of beta-amyloid and tau-protein levels may give additional information. We report five patients with clinical and radiological features of degenerative dementia with predominantly frontal involvement and one patient with primary progressive aphasia Diagnostic work-up included computed tomography (CT), magnetic resonance imaging (MRI), PET and tau-protein and beta-amyloid level determination in CSF. While neuropsychological performance varied among patients, CT and MRI demonstrated persistently frontal lobe involvement. PET revealed corresponding changes with frontal hypometabolism, but in addition, four patients (among them two with no corresponding temporal changes in CT or MRI) showed a decreased glucose uptake in the temporal cortices. CSF samples from five patients revealed elevated beta-amyloid 1-42 and tau levels in three and two patients, respectively. Reduced beta-amyloid 1-40 was found in two patients. We conclude that occurrence of clinical symptoms of frontotemporal dementia is accompanied by frontal hypometabolism regardless of additional clinical findings. The value of determination of beta-amyloid and tau protein levels remains to be determined.
M Jauss; K Herholz; L Kracht; J Pantel; T Hartmann; M Jensen; M Essig; J Schröder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  251     ISSN:  0940-1334     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-02-06     Completed Date:  2002-07-09     Revised Date:  2009-05-11    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
Dept of Neurology, University of Giessen, Germany.
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MeSH Terms
Amyloid beta-Protein / cerebrospinal fluid,  metabolism
Cerebrospinal Fluid Proteins / metabolism
Dementia / metabolism,  pathology*,  psychology*
Frontal Lobe / metabolism*,  pathology*
Magnetic Resonance Imaging
Middle Aged
Peptide Fragments / cerebrospinal fluid,  metabolism
Psychiatric Status Rating Scales
Temporal Lobe / metabolism*,  pathology*
Tomography, Emission-Computed
Tomography, X-Ray Computed
tau Proteins / cerebrospinal fluid,  metabolism
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Cerebrospinal Fluid Proteins; 0/Peptide Fragments; 0/amyloid beta-protein (1-40); 0/tau Proteins

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