| Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease. | |
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MedLine Citation:
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PMID: 21740613 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACTBackground: Paranoid delusions are a common and difficult-to-manage feature of Alzheimer's disease (AD). We investigated the neuroanatomical correlates of paranoid delusions in a cohort of AD patients, using magnetic resonance imaging (MRI) to measure regional volume and regional cortical thickness.Methods: 113 participants with probable AD were assessed for severity of disease, cognitive and functional impairment. Presence and type of delusions were assessed using the Neuropsychiatric Inventory (NPI). Structural MRI images were acquired on a 1.5T scanner, and were analyzed using an automated analysis pipeline.Results: Paranoid delusions were experienced by 23 (20.4%) of the participants. Female participants with paranoid delusions showed reduced cortical thickness in left medial orbitofrontal and left superior temporal regions, independently of cognitive decline. Male participants with delusions did not show any significant differences compared to males without delusions. An exploratory whole brain analysis of non-hypothesized regions showed reduced cortical thickness in the left insula for female participants only.Conclusion: Frontotemporal atrophy is associated with paranoid delusions in females with AD. Evidence of sex differences in the neuroanatomical correlates of delusions as well as differences in regional involvement in different types of delusions may be informative in guiding management and treatment of delusions in AD. |
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Authors:
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D Whitehead; C Tunnard; C Hurt; L O Wahlund; P Mecocci; M Tsolaki; B Vellas; C Spenger; I Kłoszewska; H Soininen; D Cromb; S Lovestone; A Simmons |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-11 |
Journal Detail:
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Title: International psychogeriatrics / IPA Volume: - ISSN: 1741-203X ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007918 Medline TA: Int Psychogeriatr Country: - |
Other Details:
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Languages: ENG Pagination: 1-9 Citation Subset: - |
Affiliation:
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MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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