| Frontotemporal dementia and primary progressive aphasia: an update. | |
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MedLine Citation:
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PMID: 20717853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Frontotemporal dementias are syndromes of progressive dysfunction of the frontal and/or temporal lobes, either unilaterally or bilaterally. These syndromes were described clinically under the terms "primary progressive aphasia" in the United States and "frontotemporal dementia" in Europe and the United Kingdom. They are diagnosed by the clinical features of a frontal lobe neurobehavioral syndrome, or a language and cognitive deterioration. In recent years, molecular genetic findings in these syndromes, especially the tau and progranulin mutations on chromosome 17, have provided a molecular and genetic foundation for the understanding of frontotemporal dementia. These disorders are distinct from Alzheimer's disease but have some overlap with the syndrome of corticobasal degeneration, and with motor neuron disease. Treatments remain very limited, mainly involving therapy for the mood and behavioral symptoms, but advances in the molecular and genetic understanding of these conditions will hopefully lead to more specific therapies in the future. |
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Authors:
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Howard S Kirshner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current neurology and neuroscience reports Volume: 10 ISSN: 1534-6293 ISO Abbreviation: Curr Neurol Neurosci Rep Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100931790 Medline TA: Curr Neurol Neurosci Rep Country: United States |
Other Details:
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Languages: eng Pagination: 504-11 Citation Subset: IM |
Affiliation:
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Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. howard.kirshner@vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aphasia, Primary Progressive*
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diagnosis,
drug therapy,
epidemiology,
genetics,
physiopathology Brain / pathology, physiopathology Frontotemporal Dementia* / diagnosis, drug therapy, epidemiology, genetics, physiopathology Humans Intercellular Signaling Peptides and Proteins / genetics Mutation tau Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/GRN protein, human; 0/Intercellular Signaling Peptides and Proteins; 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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