Document Detail

Frontoparietal hypoperfusion in Capgras syndrome: a case report and review
MedLine Citation:
PMID:  16362848     Owner:  NLM     Status:  MEDLINE    
Capgras syndrome (CS) is characterized by the delusional belief that a person, usually very close to the patient, has been replaced by a double who is physically very similar to the original. CS is relatively rare, occurring predominantly in course of schizophrenia, particularly of the paranoid sub-type, and less frequently in association with schizoaffective and affective disorder. Recent years have witnessed a sharp increase in the number of published CS cases with an organic etiology; however, CS was considered to have its origins in psychodynamic conflict. We present a patient with the CS and brain SPECT findings whom without psychiatric disorder. As an evaluation of brain SPECT, there have been found a significantly decreased blood flow in bilateral parietal regions and slightly decreased blood flow in bilateral posterior frontal regions. Cerebral dysfunction is proposed to be a central role in CS development. Unilateral right hemisphere lesions occur more frequently than the left; however, the majority of CS cases show bilateral involvement. Pathology involves many parts of the brain, most notably frontal and parietal cortex. Our findings support that frontoparietal dysfunction could be important in the pathogenesis of CS. We reviewed the neurobiology of CS and discussed our findings in this article. CS studies will give a better understanding of the neurobiological basis of psychotic experiences and may contribute to develop a paradigm on researches about other psychotic disorders.
Ibrahim Eren; Ikbal Civi; Mustafa Yildiz
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article; Review    
Journal Detail:
Title:  Türk psikiyatri dergisi = Turkish journal of psychiatry     Volume:  16     ISSN:  1300-2163     ISO Abbreviation:  Turk Psikiyatri Derg     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9425936     Medline TA:  Turk Psikiyatri Derg     Country:  Turkey    
Other Details:
Languages:  tur     Pagination:  284-90     Citation Subset:  IM    
Psikiyatri AD., Süleyman Demirel U Tip Fak., Isparta.
Vernacular Title:
Capgras sendromunda frontopariyetal hipoperfüzyon: olgu sunumu ve gözden geçirme.
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MeSH Terms
Capgras Syndrome / etiology*,  psychology*
Cerebral Cortex / blood supply,  pathology,  physiopathology*
Parietal Lobe / blood supply*
Tomography, Emission-Computed, Single-Photon

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