Document Detail

Frontonasal facial angle in chromosomally normal fetuses at 11+0 to 13+6 weeks.
MedLine Citation:
PMID:  21040200     Owner:  NLM     Status:  MEDLINE    
AIM: To establish the normal range of frontonasal angle (FNA) at 11+0 to 13+6 weeks of gestation and the feasibility of FNA measurement, evaluate the correlation of such a parameter with crown-rump length (CRL) and nuchal translucency (NT) and assess the potential of FNA in improving the performance of first trimester sonographic and biochemical screening for trisomy 21.
METHODS: We conducted a prospective study in 400 singleton uncomplicated pregnancies. FNA was obtained during maternal screening for trisomy 21. NT thickness and FNA were measured by 2D ultrasound in a midsagittal plane of the fetal profile. FNA was measured between the line along the upper surface of the frontal bone and the superior edge of the nasal profile until the echogenic tip. Determination of maternal serum free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) was committed and concomitantly evaluated by blood sample. Patient-specific risk was calculated using Fetal Medicine Foundation software (Astraia Software GMBH, Munich, Germany).
RESULTS: Mean FNA increased with CRL from 119.80° at CRL 45 mm to 125.85° at CRL 84 mm. A significant association between the FNA and NT thickness was detected, while no significant association was found between FNA and serum PAPP-A or β-hCG.
CONCLUSION: At 11+0 to 13+6 weeks FNA increases with fetal CRL and NT thickness. Such an increase is not related to serum biochemistry.
Roberta Vicario; Linda Maria Azzurra Pirollo; Cristina De Angelis; Marianovella Narcisi; Adalgisa Pietropolli; Emilio Piccione
Publication Detail:
Type:  Journal Article     Date:  2010-10-11
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2011-03-30     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1179-84     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.
Department of Surgery, Section of Gynaecology and Obstetrics, University of Rome Tor Vergata, Rome, Italy.
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MeSH Terms
Crown-Rump Length
Down Syndrome / ultrasonography
Face / ultrasonography*
Mass Screening
Nuchal Translucency Measurement
Pregnancy Trimester, First
Prospective Studies
Reference Values
Ultrasonography, Prenatal*

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