| Frontolimbic glutamate alterations in first episode schizophrenia: evidence from a magnetic resonance spectroscopy study. | |
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MedLine Citation:
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PMID: 17853298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutamatergic dysfunction has been implicated in the pathophysiology of schizophrenia. In this study we performed absolute-quantification short-echo magnetic resonance spectroscopy (MRS) in nine patients with first episode schizophrenia and 32 group-matched control subjects to test the hypothesis of glutamatergic dysfunction at disease onset. Regions of interest were the left dorsolateral prefrontal cortex and the left hippocampus. In the patient group absolute concentrations of glutamate were significantly higher in the prefrontal cortex and near-significantly higher in the hippocampus. The glutamate signals significantly correlated with rating scores for schizophreniform symptoms. Absolute-quantification [1H]MRS can reveal glutamatergic abnormalities which might play an important role in the pathogenesis and course of schizophrenia. |
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Authors:
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Hans M Olbrich; Gabriele Valerius; Nicolas Rüsch; Martin Buchert; Thorsten Thiel; Jürgen Hennig; Dieter Ebert; Ludger Tebartz Van Elst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry Volume: 9 ISSN: 1562-2975 ISO Abbreviation: World J. Biol. Psychiatry Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-23 Completed Date: 2008-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120023 Medline TA: World J Biol Psychiatry Country: Scotland |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Affiliation:
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Section for Experimental NeuroPsychiatry, Department of Psychiatry, Albert-Ludwigs-University, Freiburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amygdala / metabolism, pathology, physiopathology Brief Psychiatric Rating Scale Female Frontal Lobe* / metabolism, pathology, physiopathology Functional Laterality / physiology Glutamic Acid / metabolism* Hippocampus / metabolism, pathology, physiopathology Humans Limbic System* / metabolism, pathology, physiopathology Magnetic Resonance Spectroscopy* Male Prefrontal Cortex / metabolism, pathology, physiopathology Schizophrenia* / diagnosis, metabolism, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
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56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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