Document Detail


Fronto-limbic dysfunction in borderline personality disorder: A 18F-FDG positron emission tomography study.
MedLine Citation:
PMID:  21272937     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Several functional neuroimaging studies have demonstrated abnormalities in fronto-limbic pathways when comparing borderline personality disorder (BPD) patients with controls. The present study aimed to evaluate regional cerebral metabolism in euthymic BPD patients with similar measured impulsivity levels by means of 18F-FDG PET during resting state and to compare them against a control group. METHODS: The present study evaluates regional cerebral metabolism in 8 euthymic BPD patients with 18F-FDG PET during resting state as compared to 8 controls with similar socio-geographic characteristics. RESULTS: BPD patients presented a marked hypo-metabolism in frontal lobe and showed hyper-metabolism in motor cortex (paracentral lobules and post-central cortex), medial and anterior cingulus, occipital lobe, temporal pole, left superior parietal gyrus and right superior frontal gyrus. No significant differences appeared in basal ganglia or thalamus. CONCLUSIONS: Results reveal a dysfunction in patients' frontolimbic network during rest and provide further evidence for the importance of these regions in relation to BPD symptomatology.
Authors:
José Salavert; Miquel Gasol; Eduard Vieta; Ana Cervantes; Carlos Trampal; Juan Domingo Gispert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-25
Journal Detail:
Title:  Journal of affective disorders     Volume:  -     ISSN:  1573-2517     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Borderline Personality Disorder Institute, Psychiatry Department, Capio Hospital General de Catalunya, Sant Cugat del Vallès, Barcelona, Spain; Psychiatry Department, Hospital San Rafael, H Univ Vall d'Hebron, Barcelona, Spain.
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