Document Detail

Frontal lobe degeneration and Alzheimer's disease: a controlled study on clinical findings, volumetric brain changes and quantitative electroencephalography data.
MedLine Citation:
PMID:  8788079     Owner:  NLM     Status:  MEDLINE    
Ten patients with a clinical diagnosis of frontal lobe degeneration (FLD) were compared with a group of patients with probable Alzheimer's disease (AD) and with nondemented controls matched for gender and age. In comparison with AD, the duration of illness was slightly shorter and cognitive performance was better in patients with FLD. The greatest enlargement of cerebrospinal fluid volumes was found in FLD and this effect was most pronounced in the anterior fissure and lateral ventricles. Estimates of EEG band-power and EEG coherence in FLD were not remarkably different from nondemented controls, whereas delta- and theta-power were significantly increased in AD. These observations may indicate different disease processes with a dissociation of volumetric computed tomography and quantitative EEG changes, which may be of differential diagnostic value.
H Förstl; C Besthorn; F Hentschel; C Geiger-Kabisch; H Sattel; U Schreiter-Gasser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dementia (Basel, Switzerland)     Volume:  7     ISSN:  1013-7424     ISO Abbreviation:  Dementia     Publication Date:    1996 Jan-Feb
Date Detail:
Created Date:  1996-10-31     Completed Date:  1996-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010348     Medline TA:  Dementia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM    
Central Institute of Mental Health, Mannheim, Germany.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / cerebrospinal fluid,  pathology*,  radiography
Atrophy / pathology
Behavior / physiology
Case-Control Studies
Cognition / physiology
Frontal Lobe / pathology*,  radiography
Middle Aged
Prospective Studies
Psychiatric Status Rating Scales
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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