Document Detail


Frontal lobe abnormalities on MRS correlate with poor letter fluency in ALS.
MedLine Citation:
PMID:  22843269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine whether frontal lobe abnormalities on magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis (ALS) correlate with poor letter fluency (LF).
METHODS: Twenty-five patients with ALS (20 with definite, probable, or possible ALS and 5 with progressive muscular atrophy) performed an LF task, involving F word generation in 1 minute, and underwent MRS. Comparisons were made between patients with ALS with impaired LF and unimpaired LF based on an empirically derived cutoff score. A Spearman correlation was performed between the patient's N-acetyl acetate/creatinine-phosphocreatinine ratio (NAA/Cr) and the number of F words generated.
RESULTS: LF was impaired in 50% of patients with ALS. Patients with impaired LF had reduced NAA/Cr in the DLPFC compared with those with unimpaired LF (p = 0.007). There was a significant correlation between LF and NAA/Cr in the DLPFC (r = 0.51, p = 0.0009). The ALS Functional Rating Scale score, clinical region of motor onset, and disease category had no effect on LF or NAA/Cr in the DLPFC.
CONCLUSIONS: A reduced NAA/Cr in the DLPFC of patients with ALS is a marker of neuronal dysfunction and correlates with impaired performance on a clinical measure of executive function.
Authors:
Colin Quinn; Lauren Elman; Leo McCluskey; Katelin Hoskins; Chafic Karam; John H Woo; Harish Poptani; Sumei Wang; Sanjeev Chawla; Scott E Kasner; Murray Grossman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-25
Journal Detail:
Title:  Neurology     Volume:  79     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-07     Completed Date:  2012-10-15     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  583-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, University of Pennsylvania, PA, USA. colincq@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Amyotrophic Lateral Sclerosis / complications,  physiopathology*
Female
Frontal Lobe / physiopathology*
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Spectroscopy
Male
Middle Aged
Speech*
Speech Disorders / etiology,  physiopathology*
Grant Support
ID/Acronym/Agency:
AG015116/AG/NIA NIH HHS; AG017586/AG/NIA NIH HHS; AG032953/AG/NIA NIH HHS; NS044266/NS/NINDS NIH HHS; NS053488/NS/NINDS NIH HHS; NS063111/NS/NINDS NIH HHS; P01 AG017586/AG/NIA NIH HHS; P01 AG032953/AG/NIA NIH HHS; P50 NS053488/NS/NINDS NIH HHS; R01 AG015116/AG/NIA NIH HHS; R01 NS044266/NS/NINDS NIH HHS; R21 NS063111/NS/NINDS NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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