| Frontal cognitive dysfunction in juvenile myoclonic epilepsy. | |
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MedLine Citation:
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PMID: 18177360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of the present study was to investigate the possible frontal cognitive dysfunction in patients with juvenile myoclonic epilepsy (JME) and to compare the results with those of patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE), as well as with controls. METHODS: A total of 50 patients with JME, 40 patients with FLE, 40 patients with TLE, and 40 normal controls, all matched for age, education, and IQ, were administered tests to assess frontal functions (the Word Fluency Test and the Wisconsin Card Sorting Test [WCST]). All participants had a normal intelligence level based on the Wechsler Adult Intelligence Scale, and did not take medications other than antiepileptics (AEDs) or have a psychiatric history. RESULTS: Patients with JME had severe impairment in all administered tasks, similar to that of patients with FLE; TLE patients and controls followed in order. Multiple regression analysis did not disclose any significant effect of clinical variables on the cognitive deficits. DISCUSSION: These results clearly suggest that JME patients can show some frontal dysfunction, which may affect both epileptogenic features and cognitive processes. Further studies are needed to confirm these findings. |
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Authors:
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Ada Piazzini; Katherine Turner; Aglaia Vignoli; Raffaele Canger; Maria Paola Canevini |
Publication Detail:
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Type: Journal Article Date: 2007-12-28 |
Journal Detail:
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Title: Epilepsia Volume: 49 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-27 Completed Date: 2008-05-22 Revised Date: 2010-06-28 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 657-62 Citation Subset: IM |
Affiliation:
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Epilepsy Center, St. Paolo Hospital, Milan, Italy. ada.piazzini@ao-sanpaolo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cognition Disorders / diagnosis*, physiopathology Epilepsy, Frontal Lobe / diagnosis, physiopathology Epilepsy, Temporal Lobe / diagnosis, physiopathology Female Frontal Lobe / physiopathology* Humans Intelligence / classification Male Myoclonic Epilepsy, Juvenile / diagnosis*, physiopathology* Neuropsychological Tests / statistics & numerical data* Regression Analysis Wechsler Scales / statistics & numerical data |
| Comments/Corrections | |
Comment In:
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Epilepsy Curr. 2008 Nov-Dec;8(6):152-3
[PMID:
19127308
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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