Document Detail

Frontal cognitive dysfunction in juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  18177360     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the present study was to investigate the possible frontal cognitive dysfunction in patients with juvenile myoclonic epilepsy (JME) and to compare the results with those of patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE), as well as with controls. METHODS: A total of 50 patients with JME, 40 patients with FLE, 40 patients with TLE, and 40 normal controls, all matched for age, education, and IQ, were administered tests to assess frontal functions (the Word Fluency Test and the Wisconsin Card Sorting Test [WCST]). All participants had a normal intelligence level based on the Wechsler Adult Intelligence Scale, and did not take medications other than antiepileptics (AEDs) or have a psychiatric history. RESULTS: Patients with JME had severe impairment in all administered tasks, similar to that of patients with FLE; TLE patients and controls followed in order. Multiple regression analysis did not disclose any significant effect of clinical variables on the cognitive deficits. DISCUSSION: These results clearly suggest that JME patients can show some frontal dysfunction, which may affect both epileptogenic features and cognitive processes. Further studies are needed to confirm these findings.
Ada Piazzini; Katherine Turner; Aglaia Vignoli; Raffaele Canger; Maria Paola Canevini
Publication Detail:
Type:  Journal Article     Date:  2007-12-28
Journal Detail:
Title:  Epilepsia     Volume:  49     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-05-22     Revised Date:  2010-06-28    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657-62     Citation Subset:  IM    
Epilepsy Center, St. Paolo Hospital, Milan, Italy.
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MeSH Terms
Cognition Disorders / diagnosis*,  physiopathology
Epilepsy, Frontal Lobe / diagnosis,  physiopathology
Epilepsy, Temporal Lobe / diagnosis,  physiopathology
Frontal Lobe / physiopathology*
Intelligence / classification
Myoclonic Epilepsy, Juvenile / diagnosis*,  physiopathology*
Neuropsychological Tests / statistics & numerical data*
Regression Analysis
Wechsler Scales / statistics & numerical data
Comment In:
Epilepsy Curr. 2008 Nov-Dec;8(6):152-3   [PMID:  19127308 ]

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