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From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine.
MedLine Citation:
PMID:  20937377     Owner:  NLM     Status:  In-Data-Review    
AIM OF THE STUDY: Effects of the different fractions obtained by partition of ethanolic extract (EE) of Agelanthus dodoneifolius through column chromatography were investigated on rat blood pressure and aortic relaxation and compared to those observed in the presence of crude EE.
MATERIALS AND METHODS: The acute hypotensive activity of EE, fractions and dodoneine, administrated intravenously, was evaluated in anaesthetized rats using the invasive method of blood pressure recording. Bioassay-guided fractionation using rat aorta pre-contracted by norepinephrine to monitor the relaxant activity led to the isolation of dodoneine.
RESULTS: In normotensive rats, injection of EE (0.01-10mg/kg) produced a dose-dependent decrease in both systolic and diastolic blood pressure without any significant change in heart rate. In a similar way, the EE (0.001-3mg/mL) caused relaxation of rat pre-contracted aorta in a concentration-dependent manner. Fractionation of the EE afforded 14 fractions, F1-F14, that were tested on rat precontracted aortic rings. At the concentration level of 1mg/mL, a maximum relaxation effect was observed for fractions F2-F5. F4 was the most effective to elicit a concentration-dependent relaxation effect with an ED(50)=160±1.1 μg/mL (n=5) and to decreased systolic and diastolic control pressure by 56.9% and 81.6% respectively. F4 contains most of the dihydropyranone dodoneine, with 93% of the sample mass. Dodoneine separated from this fraction was also able to decrease both systolic and diastolic arterial pressure by 32.5% and 38.7% at 100μg/kg, respectively.
CONCLUSION: For the first time, this study demonstrates the hypotensive property of the dodoneine present in Agelanthus dodoneifolius.
M Ouedraogo; M Ruiz; E Vardelle; H Carreyre; J M Coustard; D Potreau; L L Sawadogo; C Cognard; F Becq; C Vandebrouck; J Bescond
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Publication Detail:
Type:  Journal Article     Date:  2010-10-16
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  133     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  345-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS/UMR 6187, 40 avenue du Recteur Pineau F-86022 Poitiers Cedex, France; Université de Ouagadougou, 03 BP 7021, Ouagadougou 01, Burkina Faso.
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