Document Detail

From simian virus 40 to transient shuttle vectors in mutagenesis studies.
MedLine Citation:
PMID:  2538734     Owner:  NLM     Status:  MEDLINE    
Exogenous DNA probes are frequently used to study mutagenesis in mammalian cells. Experimental protocols utilizing simian virus 40 (SV40) and transient shuttle vectors able to replicate in mammalian cells as well as in bacteria are described. The main interests and the limits of the 2 genetic assays are discussed from results obtained with both systems. Despite some minor discrepancies, results obtained are very similar using either method. The complementarity of the 2 assays will allow a better comprehension of the mechanisms by which mutations may arise in mammalian cells.
F Bourre; G Renault; A Gentil
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mutation research     Volume:  220     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1989 Mar-May
Date Detail:
Created Date:  1989-05-10     Completed Date:  1989-05-10     Revised Date:  2006-04-21    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.
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MeSH Terms
Genetic Vectors*
Mutagenicity Tests / methods*
Simian virus 40 / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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