Document Detail


From the regulation of peptidoglycan synthesis to bacterial growth and morphology.
MedLine Citation:
PMID:  22203377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintaining bacterial peptidoglycan sacculus grows. In this Review, we highlight the relationship between peptidoglycan synthesis complexes and cytoskeletal elements, as well as recent evidence that peptidoglycan growth is regulated from outside the sacculus in Gram-negative bacteria. We also discuss how growth of the sacculus is sensitive to mechanical force and nutritional status, and describe the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.
Authors:
Athanasios Typas; Manuel Banzhaf; Carol A Gross; Waldemar Vollmer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-28
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  10     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-03-09     Revised Date:  2014-09-30    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amidohydrolases / metabolism
Bacteria / growth & development*,  metabolism
Bacterial Outer Membrane Proteins / metabolism
Bacterial Proteins / metabolism
Cell Wall / metabolism
Cytoskeletal Proteins / metabolism
Cytoskeleton / metabolism
Endopeptidases / metabolism
Escherichia coli / growth & development,  metabolism
Escherichia coli Proteins / metabolism
Gene Expression Regulation, Bacterial
Gram-Negative Bacteria / growth & development,  metabolism
Hydrolysis
N-Acetylmuramoyl-L-alanine Amidase / metabolism
Peptidoglycan / biosynthesis*
Grant Support
ID/Acronym/Agency:
BB/G015902/1//Biotechnology and Biological Sciences Research Council; BBI020012/1//Biotechnology and Biological Sciences Research Council; GM085697/GM/NIGMS NIH HHS; GM085697‑01S1/GM/NIGMS NIH HHS; K99GM092984/GM/NIGMS NIH HHS; R01 GM036278/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Outer Membrane Proteins; 0/Bacterial Proteins; 0/Cytoskeletal Proteins; 0/Escherichia coli Proteins; 0/FtsZ protein, Bacteria; 0/Peptidoglycan; 149255-61-8/MreB protein, E coli; EC 3.4.-/Endopeptidases; EC 3.5.-/Amidohydrolases; EC 3.5.1.28/N-Acetylmuramoyl-L-alanine Amidase
Comments/Corrections
Comment In:
Nat Rev Microbiol. 2014 Sep;12(9):595   [PMID:  25043163 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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