| From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging. | |
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MedLine Citation:
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PMID: 19387478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite their rarity, diseases of premature aging, or "progeroid" syndromes, have provided important insights into basic mechanisms that may underlie cancer and normal aging. In this review, we highlight these recent developments in Hutchinson-Gilford progeria syndrome (HGPS), Werner syndrome, Bloom syndrome, Cockayne syndrome, trichothiodystrophy, ataxia-telangiectasia, Rothmund-Thomson syndrome, and xeroderma pigmentosum. Though they are caused by different mutations in various genes and often result in quite disparate phenotypes, deciphering the molecular bases of these conditions has served to highlight their underlying basic similarities. Studies of progeroid syndromes, particularly HGPS, the most dramatic form of premature aging, have contributed to our knowledge of fundamental processes of importance to skin biology, including DNA transcription, replication, and repair, genome instability, cellular senescence, and stem-cell differentiation. |
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Authors:
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Brian C Capell; Brook E Tlougan; Seth J Orlow |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-04-23 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 129 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-14 Completed Date: 2009-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 2340-50 Citation Subset: IM |
Affiliation:
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The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging, Premature
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genetics*,
pathology Cell Aging / genetics* DNA Damage / genetics Genomic Instability / genetics Humans Mutation / genetics Progeria / genetics, pathology Skin Neoplasms / genetics*, pathology Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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