| From polymer to size-defined oligomers: a step economy process for the efficient and stereocontrolled construction of chondroitin oligosaccharides and biotinylated conjugates thereof: part 1. | |
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MedLine Citation:
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PMID: 19575349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Controlled acid hydrolysis of polymeric chondroitin sulfate of bovine origin afforded in good yield a basic disaccharide fragment that was used for the first time as a starting material for the expeditious preparation of a set of building blocks that in turn act as versatile synthons for the efficient and stereocontrolled construction of a collection of size-defined chondroitin oligomers (from di- to octasaccharides). This step economy process allows their preparation as reducing species, fitted with a fluorophore, or as biotinylated conjugates; all useful tools for the preparation of microarrays, or as probes for the study of the biosynthesis of chondroitin sulfate. |
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Authors:
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Aude Vibert; Chrystel Lopin-Bon; Jean-Claude Jacquinet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: 15 ISSN: 1521-3765 ISO Abbreviation: Chemistry Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: Germany |
Other Details:
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Languages: eng Pagination: 9561-78 Citation Subset: IM |
Affiliation:
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Institut de Chimie Organique et Analytique, UMR 6005 Universit?? d'Orl??ans et CNRS, Universit?? d'Orl??ans, BP 6759, 45067 Orl??ans Cedex, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotinylation Cattle Chondroitin Sulfates / chemistry* Glycosylation Oligosaccharides / chemical synthesis, chemistry* Polymers / chemical synthesis*, chemistry Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Oligosaccharides; 0/Polymers; 9007-28-7/Chondroitin Sulfates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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