Document Detail

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment.
MedLine Citation:
PMID:  24173169     Owner:  NLM     Status:  In-Data-Review    
Consumer safety risk assessment of skin sensitization requires information on both consumer exposure to the ingredient through product use and the hazardous properties of the ingredient. Significant progress has been made in determining the hazard potential of ingredients without animal testing. However, hazard identification is insufficient for risk assessment, and an understanding of the dose-response is needed. Obtaining such knowledge without animal testing is challenging and requires applying available mechanistic knowledge to both assay development and the integration of these data. The recent OECD report "The Adverse Outcome Pathway for Skin Sensitization Initiated by Covalent Binding to Proteins" presents the available mechanistic knowledge of the sensitization response within an adverse outcome pathway (AOP). We propose to use this AOP as the mechanistic basis for physiologically- and mechanistically-based toxicokinetic-toxicodynamic models of the sensitization response. The approach would be informed by non-animal data, provide predictions of the dose-response required for risk assessment, and would be evaluated against human clinical data.
Cameron Mackay; Michael Davies; Vicki Summerfield; Gavin Maxwell
Related Documents :
24862959 - Semiparametric modeling of grouped current duration data with preferential reporting.
24918029 - Diagnosing the dangerous demography of manta rays using life history theory.
8449589 - A four compartment open model with first-order absorption.
24748759 - Scoring from contests.
24062439 - Robust increases in severe thunderstorm environments in response to greenhouse forcing.
23398929 - Novel biomarkers for predicting intrauterine growth restriction: a systematic review an...
21688309 - Do naturalistic enclosures provide suitable environments for zoo animals?
22154649 - X-ray fluorescence analysis of ancient and medieval brass artifacts from south moravia.
18405849 - The role of users in innovation in the pharmaceutical industry.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ALTEX     Volume:  30     ISSN:  1868-596X     ISO Abbreviation:  ALTEX     Publication Date:  2013  
Date Detail:
Created Date:  2013-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100953980     Medline TA:  ALTEX     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  473-86     Citation Subset:  IM    
Safety & Environmental Assurance Centre, Unilever, Colworth Science Park, Sharnbrook, Bedford, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In vitro and in vivo testing methods of epigenomic endpoints for evaluating endocrine disruptors.
Next Document:  A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and...