Document Detail


From the one-bead-one-compound concept to one-bead-one-reactor.
MedLine Citation:
PMID:  17397228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The one-bead-one-compound method gives access to millions of compounds that can be screened directly on the bead. Although characterization techniques are increasingly potent and reliable, problems can still be encountered in deciphering the sequence of the active compound because of sensitiveness or manipulation of the bead. ChemMatrix, a totally PEG-based resin, has resolved the synthesis of peptides of outstanding difficulty. Like other PEG-based resins, it permits on-bead screening because of its compatibility in aqueous media and has the further advantage of having a high loading, comparable to polystyrene resins. ChemMatrix beads previously swelled in water can be nicely divided into four parts that can be characterized using different analytical techniques or just stored for safety or for further testing. The four bead parts show high homogeneity and can thus be considered to be replicas.
Authors:
Mariela M Marani; Marta Paradís-Bas; Judit Tulla-Puche; Simón Côté; Silvia A Camperi; Osvaldo Cascone; Fernando Albericio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-31
Journal Detail:
Title:  Journal of combinatorial chemistry     Volume:  9     ISSN:  1520-4766     ISO Abbreviation:  J Comb Chem     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886263     Medline TA:  J Comb Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Affiliation:
Institute for Research in Biomedicine, Barcelona Science Park, Josep Samitier 1-5, 08028-Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid / methods
Combinatorial Chemistry Techniques / methods
Peptides / chemical synthesis*,  chemistry
Polyethylene Glycols / chemistry*
Resins, Synthetic / chemistry*
Sensitivity and Specificity
Water / chemistry
Chemical
Reg. No./Substance:
0/Peptides; 0/Polyethylene Glycols; 0/Resins, Synthetic; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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