Document Detail


From network models to network responses: Integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks.
MedLine Citation:
PMID:  22129227     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Many important problems in cell biology emerge from the dense nonlinear interactions between functional modules. The importance of mathematical modeling and computer simulation in understanding cellular processes is now indisputable and widely appreciated, and genome-scale metabolic models have gained much popularity and utility in helping us to understand and test hypotheses about these complex networks. However, there are some caveat utilitor that come with the use and interpretation of different types of metabolic models that we aim to highlight here. We discuss and illustrate how the integration of thermodynamic and kinetic properties of the yeast metabolic networks in network analyses can help in understanding and utilizing this organism more successfully in the areas of metabolic engineering, synthetic biology, and disease treatment.
Authors:
Keng Cher Soh; Ljubisa Miskovic; Vassily Hatzimanikatis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-30
Journal Detail:
Title:  FEMS yeast research     Volume:  -     ISSN:  1567-1364     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101085384     Medline TA:  FEMS Yeast Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Affiliation:
Laboratory of Computational Systems Biotechnology, Ecole Polytechnique Fédérale de Lausanne, Station 6, CH-1015, Lausanne, Switzerland.
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