| From nature to the laboratory and into the clinic. | |
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MedLine Citation:
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PMID: 19028103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural products possess a broad diversity of structure and function, and they provide inspiration for chemistry, biology, and medicine. In this review article, we highlight and place in context our laboratory's total syntheses of, and related studies on, complex secondary metabolites that were clinically important drugs, or have since been developed into useful medicines, namely amphotericin B (1), calicheamicin gamma(1)(I) (2), rapamycin (3), Taxol (4), the epothilones [e.g., epothilones A (5) and B (6)], and vancomycin (7). We also briefly highlight our research with other selected inspirational natural products possessing interesting biological activities [i.e., dynemicin A (8), uncialamycin (9), eleutherobin (10), sarcodictyin A (11), azaspiracid-1 (12), thiostrepton (13), abyssomicin C (14), platensimycin (15), platencin (16), and palmerolide A (17)]. |
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Authors:
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K C Nicolaou; Jason S Chen; Stephen M Dalby |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-11-06 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 17 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-06-04 Revised Date: 2011-02-09 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 2290-303 Citation Subset: IM |
Affiliation:
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Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC408, La Jolla, CA 92037, USA. kcn@scripps.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Products* / chemistry, pharmacology Drug Evaluation, Preclinical Humans Laboratories |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI055475-06/AI/NIAID NIH HHS; R01 CA100101-03/CA/NCI NIH HHS; R01 ES013314-03/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Products |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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