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From metabolic normality to cardio-metabolic risk factors in subjects with obesity.
MedLine Citation:
PMID:  22421925     Owner:  NLM     Status:  Publisher    
The aim of the study was to evaluate the 3 years incidence of cardio-metabolic risk factors, such as impaired fasting glucose, reduced HDL-cholesterol, increased plasma triglycerides or blood pressure as well as Impaired Glucose Tolerance (IGT) in over-weight or obese (ow/ob) and normal body weight (nbw) subjects metabolically normal at baseline. Subjects from the RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) study were analysed.We analyzed 284 nbw and 152 ow/ob subjects who, at baseline, did not show any of the above mentioned cardio-metabolic risk factors. At 3 years, these parameters were re-evaluated. Intima-media thickness of the common carotid artery was echographically measured.At follow-up, the incidence of one or more cardio-metabolic risk factors was 57.2% in ow/ob vs 31.7% in nbw (p<0.0001). After adjustment for age, sex, menopause status, lifestyle parameters, insulin sensitivity and fasting insulinaemia, BMI remained significantly linked to the development of one or more cardio-metabolic risk factors (p=0.02). An increased BMI at follow-up was significantly associated with the development of cardio-metabolic alterations, in both nbw and ow/ob groups (p=0.04). Ow/ob subjects who, at 3 years follow-up, remained metabolically normal, showed a less favourable cardio-metabolic profile, when compared to nbw counterparts. In ow/ob metabolically normal males and females, intima-media of the common carotid at follow-up was thicker than in nbw (p=0.03 for males, p=0.04 for females).In conclusion, metabolically normal obese subjects show a higher incidence of cardio-metabolic risk factors, in a short follow-up period. Weight gain is significantly associated with the development of these factors, in both nbw and ow/ob subjects.
Elisabetta Bobbioni-Harsch; Zoltan Pataky; Vincent Makoundou; Martine Laville; Emmanuel Disse; Christian H Anderwald; Thomas Konrad; Alain Golay
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-16
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-7381     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Service of Therapeutic Education for Chronic Diseases, WHO Collaborating Centre, Geneva University Hospital, Geneva, Switzerland.
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