| From mesial temporal lobe to temporoperisylvian seizures: a quantified study of temporal lobe seizure networks. | |
| | |
MedLine Citation:
|
PMID: 20738379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: The determination of epileptogenic structures in partial epilepsy is crucial in the context of epilepsy surgery. In this study we have quantified the "epileptogenicity" of mesial temporal lobe structures (M), lateral neocortical regions (L), and extratemporal perisylvian structures (ET) in patients with temporal lobe epilepsy (TLE), in order to classify the brain networks involved in seizure generation. METHODS: Thirty-four patients having TLE investigated by intracerebral recordings using stereotactic electroencephalography (EEG) (SEEG) were selected. Epileptogenicity of M, L, and ET structures was quantified according to the "epileptogenicity index" (EI), a new way to quantify rapid discharges at seizure onset, ranging from 0 (no epileptogenicity) to 1 (maximal epileptogenicity). RESULTS: Automatic clustering using EI values from M, L, and ET separated patients into four classes: mesial group (max EI in M), lateral group (max EI in L), mesiolateral group (high EI in both M and L) and temporoperisylvian group (TPS) (high values in ET). The median number of highly epileptogenic structures (defined by EI >0.3) was four, a result confirming that most TLE is organized as "epileptogenic networks." We found that the duration of epilepsy was correlated with the number of epileptogenic structures and that surgical prognosis was also related to the extent of the epileptogenicity in the brain. CONCLUSIONS: Several distinct epileptogenic networks are involved in seizure generation in TLE. Findings advocate for a progressive recruitment of epileptogenic structures in human brain with time. |
| | |
Authors:
|
Fabrice Bartolomei; Delphine Cosandier-Rimele; Aileen McGonigal; Sandrine Aubert; Jean Régis; Martine Gavaret; Fabrice Wendling; Patrick Chauvel |
Related Documents
:
|
9867139 - Crossed cerebellar diaschisis due to intracranial hematoma in basal ganglia or thalamus. 11418859 - Spatial awareness is a function of the temporal not the posterior parietal lobe. 11461709 - Corticosteroids and cognition. 6506109 - Ct-cbf correlations of cognitive deficits in multi-infarct dementia. 1915169 - Magnetoencephalographic localization of subdural dipoles in a patient with temporal lob... 9829819 - Upper motor neuron predominant degeneration with frontal and temporal lobe atrophy. 3323929 - Quantitative changes in some subcortical nuclei in aging, alzheimer's disease and parki... 15967089 - Experimental electrical stimulation therapy for epilepsy. 17134649 - The woman who needed a pet. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Epilepsia Volume: 51 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-11-02 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
|
Languages: eng Pagination: 2147-58 Citation Subset: IM |
Copyright Information:
|
Wiley Periodicals, Inc. © 2010 International League Against Epilepsy. |
Affiliation:
|
INSERM, U751, Laboratoire de Neurophysiologie et Neuropsychologie, Marseille, France. fabrice.bartolomei@ap-hm.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anterior Temporal Lobectomy
/
methods Anticonvulsants / therapeutic use Brain / physiopathology*, surgery Brain Mapping Cerebral Cortex / physiopathology, surgery Cluster Analysis Drug Resistance Electrodes, Implanted Electroencephalography / statistics & numerical data Epilepsies, Partial / diagnosis, physiopathology*, surgery Epilepsy, Temporal Lobe / diagnosis, physiopathology*, surgery Functional Laterality / physiology Humans Neocortex / physiopathology Nerve Net / physiopathology* Neurosurgical Procedures Radiosurgery Stereotaxic Techniques Temporal Lobe / physiopathology, surgery |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of SUDEP in a patient with Dravet syndrome with SCN1A mutation.
Next Document: Generalized convulsive status epilepticus management in adults: a cohort study with evaluation of pr...