Document Detail


From malnutrition to refeeding during anorexia nervosa.
MedLine Citation:
PMID:  10565398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anorexia nervosa is one of the most common forms of malnutrition observed in Western society in individuals without physical diseases, with an average risk of mortality of 20% in a younger population aged between 15 and 25 years. It is characterised by an initial dramatic decrease in food intake that leads to profound depletion in muscle and fat mass. During the course of the disease, the resting energy expenditure decreases proportionally to the loss of lean body mass with a decrease in thyroid hormone secretion. The metabolic adaptation during anorexia nervosa is similar to that observed during starvation with a relative sparing of protein stores. After an initial weight loss, the total energy expenditure is similar to that in normal individuals, with a decrease in resting energy expenditure and an increased energy-related physical activity. At the end stage of wasting, however, physical activity dramatically decreases as well as energy intake. This metabolic adaptation of semi-starvation is impaired during refeeding with an increase in the thermic effect of food and a high risk of refeeding syndrome with severe hypophosphatemia.
Authors:
J C Melchior
Related Documents :
14520248 - Selective underreporting of energy intake in women: magnitude, determinants, and effect...
2869978 - Autonomic and endocrine factors in the regulation of energy balance.
1252398 - Food intake and energy expenditure of indian troops in training.
8269888 - Consumer estimates of the percentage energy from fat in common foods.
18027758 - Defining and measuring the impact of dynamic traits on interspecific interactions.
985438 - Liposomal retention of a modified anti-inflammatory steroid.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  1     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  481-5     Citation Subset:  IM    
Affiliation:
Nutrition Clinique, Hôpital Raymond Poincaré, Garches, France. jean-claude.melchior@rpc.ap-hop-paris.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anorexia Nervosa / physiopathology*,  rehabilitation*
Body Composition
Diet Therapy*
Energy Metabolism
Humans
Nutrition Disorders / etiology,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In-vivo measurement of protein synthesis in humans.
Next Document:  Assessment of status.