Document Detail

From malnutrition to refeeding during anorexia nervosa.
MedLine Citation:
PMID:  10565398     Owner:  NLM     Status:  MEDLINE    
Anorexia nervosa is one of the most common forms of malnutrition observed in Western society in individuals without physical diseases, with an average risk of mortality of 20% in a younger population aged between 15 and 25 years. It is characterised by an initial dramatic decrease in food intake that leads to profound depletion in muscle and fat mass. During the course of the disease, the resting energy expenditure decreases proportionally to the loss of lean body mass with a decrease in thyroid hormone secretion. The metabolic adaptation during anorexia nervosa is similar to that observed during starvation with a relative sparing of protein stores. After an initial weight loss, the total energy expenditure is similar to that in normal individuals, with a decrease in resting energy expenditure and an increased energy-related physical activity. At the end stage of wasting, however, physical activity dramatically decreases as well as energy intake. This metabolic adaptation of semi-starvation is impaired during refeeding with an increase in the thermic effect of food and a high risk of refeeding syndrome with severe hypophosphatemia.
J C Melchior
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  1     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  481-5     Citation Subset:  IM    
Nutrition Clinique, Hôpital Raymond Poincaré, Garches, France.
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MeSH Terms
Anorexia Nervosa / physiopathology*,  rehabilitation*
Body Composition
Diet Therapy*
Energy Metabolism
Nutrition Disorders / etiology,  physiopathology*

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