| From macro- to microcirculation: benefits in hypertension and diabetes. | |
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MedLine Citation:
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PMID: 19363848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic hypertension and diabetes produce both macrovascular and microvascular pathophysiological changes. Greater arterial stiffness increases central systolic and pulse pressure, which raises left ventricular afterload and reduces coronary perfusion. Resistance arteries remodelling and capillary rarefaction increase peripheral resistance, thereby contributing to hypertension and amplifying the detrimental haemodynamic effects of arterial stiffening. The result is target organ impairment, such as left ventricular hypertrophy, decreased coronary perfusion pressure, reduced coronary reserve and further vascular remodelling, culminating in coronary artery disease and stroke. Therapeutic intervention is possible and necessary to stop these vascular changes. Vasodilating antihypertensive drugs, such as the perindopril/indapamide combination, have been shown to modify both arterial and arteriolar remodelling, leading to reduced central systolic blood pressure and enhancing vascular bed perfusion. These effects probably underpin the benefits of these agents in reducing cardiovascular morbidity and mortality. |
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Authors:
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Enrico Agabiti-Rosei |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 26 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2009-04-14 Completed Date: 2009-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: England |
Other Details:
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Languages: eng Pagination: S15-9 Citation Subset: IM |
Affiliation:
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Clinica Medica, Università degli Studi di Brescia, Dipartimento di Medicina, Spedali Civili di Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 2
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complications*,
therapy Humans Hypertension / complications*, physiopathology*, therapy Microcirculation* Regional Blood Flow* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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