Document Detail

From low arterial- to low tissue-oxygenation strategy. An evolutionary theory.
MedLine Citation:
PMID:  11718757     Owner:  NLM     Status:  MEDLINE    
The primitive atmosphere where aerobic life started on earth was hypoxic and hypercapnic. Remarkably, an adaptation strategy whereby O(2) partial pressure, P(O(2)), in the arterial blood is maintained within a low and narrow range of 1-3 kPa, largely independent of inspired P(O(2)), has also been reported in modern water-breathers. In mammalian tissues, including brain, the most frequently measured P(O(2)) is in the same low range. Based on the postulate that basic cellular machinery has been established since the early stages of evolution, we propose that this similarity in oxygenation status is the consequence of an early adaptation strategy which, subsequently throughout the course of evolution, maintained cellular oxygenation in the same low and primitive range independent of environmental changes. The rational for such an evolutionary theory is discussed in terms of an equilibrium between physiological and pathological reactions associated with O(2) excess vs O(2) lack and emerging concepts about the importance of cellular O(2)-dependent mechanisms in the low but physiological P(O(2)) range.
J C Massabuau
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Respiration physiology     Volume:  128     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-23     Completed Date:  2002-02-04     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  249-61     Citation Subset:  IM    
Laboratoire d'Ecophysiologie et Ecotoxicologie des Systèmes Aquatiques, UMR 5805, Université Bordeaux 1 and CNRS, Place du Dr B. Peyneau, 33120, Arcachon, France.
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MeSH Terms
Cell Respiration / physiology
Homeostasis / physiology*
Oxygen / blood*
Partial Pressure
Reg. No./Substance:

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